Trace Element Levels in Patients with Familial Mediterranean Fever

Overview

Journal Eurasian J Med

Publisher Aves

Specialty General Medicine

Date 2015 Jan 23

PMID 25610168

Citations 1

Authors

Kadir Yildirim

Hulya Uzkeser

Abdullah Uyanik

Saliha Karatay

Ahmet Kiziltunc

Affiliations

Soon will be listed here.

Abstract

Objective: Although the genetic etiology of familial Mediterranean fever (FMF) is known, limited information is available regarding the regulation of inflammation during attack-free periods. The aim of this study was to determine the alterations in serum copper (Cu), zinc (Zn) and selenium (Se) levels that may be associated with inflammation during attack-free periods in FMF patients.

Materials And Methods: This study included 33 patients with FMF and 30 healthy volunteers. Erythrocyte sedimentation rate (ESR), the serum C-reactive protein (CRP) level and serum levels of Cu, Zn and Se in FMF patients and healthy volunteers were assessed by the atomic absorption spectrophotometry method.

Results: ESR and serum CRP levels and serum Cu and Zn levels were similar between patients with FMF during an attack-free period and healthy controls (p>0.05). Serum Se levels in the patient group were significantly higher than in the control group (p<0.05).

Conclusion: Our study shows that levels of trace elements in serum are variable in patients with FMF during attack-free periods. Serum Se concentrations may at least in part contribute to the subclinical inflammation in FMF patients during attack-free periods. However, further studies are necessary to confirm this result.

Citing Articles

Relationship between serum interleukin-1beta levels and acute phase response proteins in patients with familial Mediterranean fever.

Yildirim K, Uzkeser H, Keles M, Karatay S, Kiziltunc A, Kaya M Biochem Med (Zagreb). 2012; 22(1):109-13.

PMID: 22384525 PMC: 4062326. DOI: 10.11613/bm.2012.012.

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