Foot Infection by Clostridium Sordellii: Case Report and Review of 15 Cases in France

Overview

Journal J Clin Microbiol

Specialty Microbiology

Date 2015 Jan 23

PMID 25609723

Citations 8

Authors

Philippe Bouvet

Jean Sautereau

Alain Le Coustumier

Francine Mory

Christiane Bouchier

Michel-R Popoff

Affiliations

Soon will be listed here.

Abstract

We report a case of foot infection by Clostridium sordellii and review 15 human infections registered at a Reference Center in France during the period 1998 to 2011. All strains were found nontoxigenic, lacking the lethal toxin gene coding for TcsL. Like Clostridium septicum, several C. sordellii infections were associated with intestinal neoplasms.

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References

Bouvet P, Ruimy R, Bouchier C, Faucher N, Mazuet C, Popoff M . An atypical Clostridium strain related to the Clostridium botulinum group III strain isolated from a human blood culture. J Clin Microbiol. 2013; 52(1):339-43. PMC: 3911442. DOI: 10.1128/JCM.00390-13. View

Genth H, Pauillac S, Schelle I, Bouvet P, Bouchier C, Varela-Chavez C . Haemorrhagic toxin and lethal toxin from Clostridium sordellii strain vpi9048: molecular characterization and comparative analysis of substrate specificity of the large clostridial glucosylating toxins. Cell Microbiol. 2014; 16(11):1706-21. DOI: 10.1111/cmi.12321. View

Ho C, Bhatnagar J, Cohen A, Hacker J, Zane S, Reagan S . Undiagnosed cases of fatal Clostridium-associated toxic shock in Californian women of childbearing age. Am J Obstet Gynecol. 2009; 201(5):459.e1-7. DOI: 10.1016/j.ajog.2009.05.023. View

Smith C, Goslin B . Clostridium sordellii surgical site infection after breast mass excision: case report. Surg Infect (Larchmt). 2012; 14(1):160-2. DOI: 10.1089/sur.2011.060. View

Tait A, Dalton M, Geny B, DAgnillo F, Popoff M, Sternberg E . The large clostridial toxins from Clostridium sordellii and C. difficile repress glucocorticoid receptor activity. Infect Immun. 2007; 75(8):3935-40. PMC: 1951967. DOI: 10.1128/IAI.00291-07. View

Cohen A, Bhatnagar J, Reagan S, Zane S, DAngeli M, Fischer M . Toxic shock associated with Clostridium sordellii and Clostridium perfringens after medical and spontaneous abortion. Obstet Gynecol. 2007; 110(5):1027-33. DOI: 10.1097/01.AOG.0000287291.19230.ba. View

Walk S, Jain R, Trivedi I, Grossman S, Newton D, Thelen T . Non-toxigenic Clostridium sordellii: clinical and microbiological features of a case of cholangitis-associated bacteremia. Anaerobe. 2011; 17(5):252-6. PMC: 3183353. DOI: 10.1016/j.anaerobe.2011.06.009. View

Miech R . Pathophysiology of mifepristone-induced septic shock due to Clostridium sordellii. Ann Pharmacother. 2005; 39(9):1483-8. DOI: 10.1345/aph.1G189. View

Boehm C, Gibert M, Geny B, Popoff M, Rodriguez P . Modification of epithelial cell barrier permeability and intercellular junctions by Clostridium sordellii lethal toxins. Cell Microbiol. 2006; 8(7):1070-85. DOI: 10.1111/j.1462-5822.2006.00687.x. View

10.

Aronoff D, Thelen T, Walk S, Petersen K, Jackson J, Grossman S . Pseudo-outbreak of Clostridium sordellii infection following probable cross-contamination in a hospital clinical microbiology laboratory. Infect Control Hosp Epidemiol. 2010; 31(6):640-2. PMC: 3086061. DOI: 10.1086/652774. View

11.

Soper D . Abortion and clostridial toxic shock syndrome. Obstet Gynecol. 2007; 110(5):970-1. DOI: 10.1097/01.AOG.0000288224.47104.7b. View

12.

Clark S . Sudden death in periparturient sheep associated with Clostridium sordellii. Vet Rec. 2003; 153(11):340. View

13.

Couzin J . infectious disease. RU-486-linked deaths open debate about risky bacteria. Science. 2006; 312(5776):986. DOI: 10.1126/science.312.5776.986. View

14.

Kimura A, Higa J, Levin R, Simpson G, Vargas Y, Vugia D . Outbreak of necrotizing fasciitis due to Clostridium sordellii among black-tar heroin users. Clin Infect Dis. 2004; 38(9):e87-91. DOI: 10.1086/383471. View

15.

Zane S, Guarner J . Gynecologic clostridial toxic shock in women of reproductive age. Curr Infect Dis Rep. 2011; 13(6):561-70. DOI: 10.1007/s11908-011-0207-7. View

16.

Matten J, Buechner V, Schwarz R . A rare case of Clostridium sordellii bacteremia in an immunocompromised patient. Infection. 2009; 37(4):368-9. DOI: 10.1007/s15010-008-8192-y. View

17.

Murray S, Wooltorton E . Septic shock after medical abortions with mifepristone (Mifeprex, RU 486) and misoprostol. CMAJ. 2005; 173(5):485. PMC: 1188182. DOI: 10.1503/cmaj.050980. View

18.

Popoff M . Bacteriological examination in enterotoxaemia of sheep and lamb. Vet Rec. 1984; 114(13):324. DOI: 10.1136/vr.114.13.324. View

19.

Abdulla A, Yee L . The clinical spectrum of Clostridium sordellii bacteraemia: two case reports and a review of the literature. J Clin Pathol. 2000; 53(9):709-12. PMC: 1731239. DOI: 10.1136/jcp.53.9.709. View

20.

McGregor J, Soper D, Lovell G, TODD J . Maternal deaths associated with Clostridium sordellii infection. Am J Obstet Gynecol. 1989; 161(4):987-95. DOI: 10.1016/0002-9378(89)90768-0. View