Increase in the Oxidised Low-density Lipoprotein Level by Smoking and the Possible Inhibitory Effect of Statin Therapy in Patients with Cardiovascular Disease: a Retrospective Study

Overview

Journal BMJ Open

Specialty General Medicine

Date 2015 Jan 23

PMID 25609666

Citations 11

Authors

Kazuo Ogawa

Toshikazu Tanaka

Tomohisa Nagoshi

Hiroshi Sekiyama

Satoshi Arase

Kosuke Minai

Takayuki Ogawa

Michihiro Yoshimura

Affiliations

Soon will be listed here.

Abstract

Objectives: Malondialdehyde-modified low-density lipoprotein (MDA-LDL) level is a marker of oxidative stress and is linked to progression of arteriosclerosis; however, the clinical factors affecting the oxidised LDL level have not been elucidated. We investigate various factors to identify correlation with MDA-LDL level in high-risk patients requiring catheter intervention.

Setting: Secondary care (cardiology), single-centre study.

Participants: 600 patients who were admitted to our hospital and underwent cardiac catheterisation.

Primary And Secondary Outcome Measures: Blood samples were obtained to measure lipid profiles and MDA-LDL level.

Results: With regard to smoking status, MDA-LDL level was significantly higher in ex-smokers/current smokers compared with non-smokers. Of note, there was no improvement of MDA-LDL level even in patients who had quit smoking. Multiple regression analysis showed that MDA-LDL level was positively correlated with LDL-cholesterol (LDL-C) level, Brinkman index and male gender. The correlation between smoking status and either MDA-LDL or LDL-C level was investigated in two groups: namely, patients with and patients without statin treatment. In the non-statin group, MDA-LDL level and MDA-LDL/LDL-C ratio were significantly higher in ex-smokers/current smokers compared with non-smokers, while no significant correlation was observed between smoking status and LDL-C level. In contrast, in the statin group, there were no significant correlations between smoking status and any of the cholesterol parameters.

Conclusions: We found that MDA-LDL level was affected by multiple factors, such as smoking status, LDL-C level and male gender. The present findings give additional evidence that smoking should be prohibited from a MDA-LDL standpoint. Furthermore, statin therapy might have a beneficial effect on the reduction of MDA-LDL level.

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