Association of the Histone-lysine N-methyltransferase MLL5 Gene with Coronary Artery Disease in Chinese Han People

Overview

Journal Meta Gene

Publisher Elsevier

Specialty Genetics

Date 2015 Jan 22

PMID 25606435

Citations 5

Authors

Qinghua Yuan

Xiang Xie

Zhenyan Fu

Xiang Ma

Yining Yang

Ding Huang

Fen Liu

Chuanfang Dai

Yitong Ma

Affiliations

Soon will be listed here.

Abstract

Background: MLL5, a member of the histone-lysine N-methyltransferase family, has been implicated in the control of the cell cycle progression and survival. The aim of this study was to explore the relationship between the interaction of histone-lysine N-methyltransferase MLL5 gene polymorphism and CAD in a Chinese Han population.

Methods: Using a case-control study of Chinese CAD patients (n = 565) and healthy controls (n = 694), we investigated the MLL5 gene polymorphism by the use of polymerase chain reaction fragment length polymorphism (PCR-RFLP) analysis.

Results: For total, the distribution of SNP1 (rs12671368) and SNP2 (rs2192932) genotypes showed a significant difference between CAD and control participants (P1 = 0.03, P2 = 0.02). For total the distribution of SNP1 (rs12671368) and SNP2 (rs2192932) alleles in the dominant model (GG vs. AA + AG) and the recessive model (AA vs. AG + GG) showed a significant difference between CAD and control participants (for allele: P1 < 0.01 and P2 = 0.05, for dominant model: P1 > 0.05 and P2 = 0.02, for recessive model: P1 = 0.03 and P2 = 0.78, respectively). For total the significant difference of the distribution of SNP1 and SNP2 in the dominant model and recessive model was retained after adjusting for covariates (for dominant model: SNP1 OR: 1.68, 95% confidence interval [CI]: 1.08-2.64, P = 0.02; SNP2 OR: 0.51, 95% CI: 0.36-0.72, P = 0.01; for recessive model: SNP1 OR: 1.84, 95% confidence interval [CI]: 1.28-2.64, P < 0.01; SNP2 OR: 0.65, 95% CI: 0.35-1.22, P = 0.18).

Conclusions: The GG genotype of rs12671368 and the AA genotype of rs2192932 in the MLL5 gene could be protective genetic markers of CAD.

Citing Articles

Association of MLL3 and TGF-β signaling gene polymorphisms with the susceptibility and prognostic outcomes of Stanford type B aortic dissection : MLL3 with TGF-β signal pathway association with Stanford type B AD.

Yuan Q, Chang Y, Jiang P, Sun L, Ma Y, Ma X BMC Cardiovasc Disord. 2023; 23(1):275.

PMID: 37226099 PMC: 10210388. DOI: 10.1186/s12872-023-03287-8.

Case Report: A Novel Splice Site Variant as a Cause of O'Donnell-Luria-Rodan Syndrome in a Male Patient.

Cao Z, Wang C, Chen J, Guo H, Wu C, Zhang G Front Pediatr. 2022; 10:822096.

PMID: 35273928 PMC: 8901719. DOI: 10.3389/fped.2022.822096.

Cell‑specific histone modifications in atherosclerosis (Review).

Jiang W, Agrawal D, Boosani C Mol Med Rep. 2018; 18(2):1215-1224.

PMID: 29901135 PMC: 6072136. DOI: 10.3892/mmr.2018.9142.

TT genotype of rs2941484 in the human HNF4G gene is associated with hyperuricemia in Chinese Han men.

Chen B, Chen X, Pan S, Yang Y, He C, Liu F Oncotarget. 2017; 8(16):26918-26926.

PMID: 28460474 PMC: 5432307. DOI: 10.18632/oncotarget.15851.

MLL5 (KMT2E): structure, function, and clinical relevance.

Zhang X, Novera W, Zhang Y, Deng L Cell Mol Life Sci. 2017; 74(13):2333-2344.

PMID: 28188343 PMC: 11107642. DOI: 10.1007/s00018-017-2470-8.

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