γδ T Cells and Dendritic Cells in Refractory Lyme Arthritis

Overview

Journal J Leukoc Biol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 2015 Jan 22

PMID 25605869

Citations 5

Authors

Ali Divan

Ralph C Budd

Richard P Tobin

M Karen Newell-Rogers

Affiliations

Soon will be listed here.

Abstract

Lyme disease is a multisystem infection transmitted by tick vectors with an incidence of up to 300,000 individuals/yr in the United States. The primary treatments are oral or i.v. antibiotics. Despite treatment, some individuals do not recover and have prolonged symptoms affecting multiple organs, including the nervous system and connective tissues. Inflammatory arthritis is a common symptom associated with Lyme pathology. In the past decades, γδ T cells have emerged as candidates that contribute to the transition from innate to adaptive responses. These cells are also differentially regulated within the synovia of patients affected by RLA. Here, we review and discuss potential cellular mechanisms involving γδ T cells and DCs in RLA. TLR signaling and antigen processing and presentation will be the key concepts that we review in aid of understanding the impact of γδ T cells in RLA.

Citing Articles

Cell-Mediated Cytotoxicity in Lyme Arthritis.

Ordonez D, Lochhead R, Strle K, Pianta A, Arvikar S, van Rhijn I Arthritis Rheumatol. 2022; 75(5):782-793.

PMID: 36413215 PMC: 10191881. DOI: 10.1002/art.42408.

Lyme arthritis: linking infection, inflammation and autoimmunity.

Lochhead R, Strle K, Arvikar S, Weis J, Steere A Nat Rev Rheumatol. 2021; 17(8):449-461.

PMID: 34226730 PMC: 9488587. DOI: 10.1038/s41584-021-00648-5.

Host transcriptome response to Borrelia burgdorferi sensu lato.

Thompson D, Watt J, Brissette C Ticks Tick Borne Dis. 2020; 12(2):101638.

PMID: 33360384 PMC: 8127729. DOI: 10.1016/j.ttbdis.2020.101638.

Immune Response to : Lessons from Lyme Disease Spirochetes.

Bockenstedt L, Wooten R, Baumgarth N Curr Issues Mol Biol. 2020; 42:145-190.

PMID: 33289684 PMC: 10842262. DOI: 10.21775/cimb.042.145.

Borrelia burgdorferi adhere to blood vessels in the dura mater and are associated with increased meningeal T cells during murine disseminated borreliosis.

Divan A, Casselli T, Narayanan S, Mukherjee S, Zawieja D, Watt J PLoS One. 2018; 13(5):e0196893.

PMID: 29723263 PMC: 5933741. DOI: 10.1371/journal.pone.0196893.

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