Natural Infection with the Porcine Respiratory Coronavirus Induces Protective Lactogenic Immunity Against Transmissible Gastroenteritis

Overview

Journal Vet Microbiol

Specialties Microbiology
Veterinary Medicine

Date 1989 Nov 1

PMID 2560280

Citations 18

Authors

S Bernard

E Bottreau

J M Aynaud

P Have

J Szymansky

Affiliations

Soon will be listed here.

Abstract

Our objective was to evaluate the level of passive protection against transmissible gastroenteritis (TGE) among 57 newborn piglets nursing from seven seropositive sows previously naturally infected with porcine respiratory coronavirus (PRCV). After challenge exposure we observed mortality rates of 44% for litters of seven PRCV-infected sows, 40% for litters of four sows orally immunized with the attenuated TGEV strain Nouzilly, and 91% for litters of seven seronegative susceptible sows. A blocking ELISA with two appropriate monoclonal antibodies distinguished serological responses of PRCV-infected sows from those of TGEV-immunized sows. The results suggest that natural infection of the sow with PRCV may induce a degree of protective lactogenic immunity against TGE.

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References

Delmas B, Gelfi J, Laude H . Antigenic structure of transmissible gastroenteritis virus. II. Domains in the peplomer glycoprotein. J Gen Virol. 1986; 67 ( Pt 7):1405-18. DOI: 10.1099/0022-1317-67-7-1405. View

Pensaert M, Callebaut P, Vergote J . Isolation of a porcine respiratory, non-enteric coronavirus related to transmissible gastroenteritis. Vet Q. 1986; 8(3):257-61. DOI: 10.1080/01652176.1986.9694050. View

Brown I, Cartwright S . New porcine coronavirus?. Vet Rec. 1986; 119(11):282-3. DOI: 10.1136/vr.119.11.282. View

Kemeny L, Wiltsey V, Riley J . Upper respiratory infection of lactating sows with transmissible gastroenteritis virus following contact exposure to infected piglets. Cornell Vet. 1975; 65(3):352-62. View

HAELTERMAN E . On the pathogenesis of transmissible gastroenteritis of swine. J Am Vet Med Assoc. 1972; 160(4):534-40. View

Kemeny L, Woods R . Quantitative transmissible gastroenteritis virus shedding patterns in lactating sows. Am J Vet Res. 1977; 38(3):307-10. View

Grom J, Bernard S . Virus enzyme-linked cell immunoassay (VELCIA): detection and titration of rotavirus antigen and demonstration of rotavirus neutralizing and total antibodies. J Virol Methods. 1985; 10(2):135-44. DOI: 10.1016/0166-0934(85)90099-0. View

Callebaut P, Correa I, Pensaert M, Jimenez G, Enjuanes L . Antigenic differentiation between transmissible gastroenteritis virus of swine and a related porcine respiratory coronavirus. J Gen Virol. 1988; 69 ( Pt 7):1725-30. DOI: 10.1099/0022-1317-69-7-1725. View

Garwes D, Stewart F, CARTWRIGHT S, Brown I . Differentiation of porcine coronavirus from transmissible gastroenteritis virus. Vet Rec. 1988; 122(4):86-7. DOI: 10.1136/vr.122.4.86. View

10.

Aynaud J, Nguyen T, Bottreau E, Brun A, Vannier P . Transmissible gastroenteritis (TGE) of swine: survivor selection of TGE virus mutants in stomach juice of adult pigs. J Gen Virol. 1985; 66 ( Pt 9):1911-7. DOI: 10.1099/0022-1317-66-9-1911. View

11.

Nguyen T, Bernard S, Bottreau E, Lantier I, Aynaud J . Étude comparée de trois souches du coronavirus de la gastroentérite transmissible: Conditions de la réplicationvirale et de la synthèse des antigènes structuraux. Ann Inst Pasteur Virol. 2020; 138(3):315-330. PMC: 7135054. DOI: 10.1016/S0769-2617(87)80018-7. View

12.

Laude H, Gelfi J, Aynaud J . In vitro properties of low- and high-passaged strains of transmissible gastroenteritis coronavirus of swine. Am J Vet Res. 1981; 42(3):447-9. View