Lack of Alpha-1-adrenergic Receptor-mediated Downregulation of Angiotensin II Receptors in Neuronal Cultures from Spontaneously Hypertensive Rat Brain

Overview

Journal Mol Cell Biochem

Publisher Springer

Specialty Biochemistry

Date 1989 Nov 19

PMID 2560138

Citations 1

Authors

M K Raizada

C Sumners

Affiliations

Soon will be listed here.

Abstract

Neuronal cells from Wistar Kyoto (WKY) and spontaneously hypertensive (SH) rat brains were established in culture to compare the expression of angiotensin II (Ang II) specific receptors and their regulation by norepinephrine (NE). Neurons from SH rat brains possess twice more Ang II specific receptors and expressed a proportional increase in Ang II stimulated [3H]-NE uptake compared with WKY neurons. NE caused a dose-dependent decrease in 125I-Ang II binding in WKY neurons, an effect not observed when neurons from SH rat brains were incubated with NE. These observations suggest that the lack of NE-induced downregulation of Ang II receptors in neuronal cultures is genetically regulated.

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PMID: 20962112 PMC: 3023215. DOI: 10.1152/ajprenal.00088.2010.

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