Anti-Inflammatory Effects of Water Chestnut Extract on Cytokine Responses Via Nuclear Factor-κB-signaling Pathway

Overview

Journal Biomol Ther (Seoul)

Specialty Pharmacology

Date 2015 Jan 17

PMID 25593649

Citations 12

Authors

Bora Kim

Jin Eun Kim

Byung-Kook Choi

Hyun-Soo Kim

Affiliations

Soon will be listed here.

Abstract

Water chestnut (Trapa japonica Flerov.) is an annual aquatic plant. In the present study, we showed that the treatment of water chestnut extracted with boiling water resulted in a significant increase 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging activity and decrease the intracellular H2O2-induced accumulation of reactive oxygen species. In addition, water chestnut extract (WCE) inhibited lipopolysaccharide (LPS)-induced nitric oxide production and suppressed mRNA and protein expression of the inducible nitric oxide synthase gene. The cytokine array results showed that WCE inhibited inflammatory cytokine secretion. Also, WCE reduced tumor necrosis factor-α-and interleukin-6-induced nuclear factor-αB activity. Furthermore, during sodium lauryl sulfate (SLS)-induced irritation of human skin, WCE reduced SLS-induced skin erythema and improved barrier regeneration. These results indicate that WCE may be a promising topical anti-inflammatory agent.

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