A Novel IgM-H-ficolin Complement Pathway to Attack Allogenic Cancer Cells in Vitro

Overview

Journal Sci Rep

Specialty Science

Date 2015 Jan 17

PMID 25592840

Citations 10

Authors

Xiaoying Lei

ChaoXu Liu

Kazem Azadzoi

Cuiling Li

Fan Lu

An Xiang

Jianbin Sun

Yanhai Guo

Qingchuan Zhao

Zhen Yan

Jinghua Yang

Affiliations

Soon will be listed here.

Abstract

The pentameric serum IgMs are critical to immune defense and surveillance through cytotoxicity against microbes and nascent cancer cells. Ficolins, a group of oligomeric lectins with an overall structure similar to C1q and mannose-binding lectin (MBL) participate in microbe infection and apoptotic cell clearance by activating the complement lectin pathway or a primitive opsonophagocytosis. It remains unknown whether serum IgMs interplay with ficolins in cancer immunosurveillance. Here we report a natural cancer killing of different types of cancer cells by sera from a healthy human population mediated by a novel IgM-H-ficolin complement activation pathway. We demonstrate for the first time that H-ficolin bound to a subset of IgMs in positive human sera and IgM-H-ficolin deposited on cancer cells to activate complement attack in cancer cells. Our data suggest that the IgM-H-ficolin -mediated complement activation pathway may be another defensive strategy for human cancer immunosurveillance.

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