Potential Role of (18)F-2-fluoro-2-deoxy-glucose Positron Emission Tomography/computed Tomography Imaging in Patients Presenting with Generalized Lymphadenopathy

Overview

Journal Indian J Nucl Med

Specialty Nuclear Medicine

Date 2015 Jan 16

PMID 25589803

Citations 1

Authors

Sellam Karunanithi

Ganesh Kumar

Punit Sharma

Chandrasekhar Bal

Rakesh Kumar

Affiliations

Soon will be listed here.

Abstract

Generalized lymphadenopathy is a common and often vexing clinical problem caused by various inflammatory, infective and malignant diseases. We aimed to review briefly and highlight the potential role of (18)F-2-fluoro-2-deoxy-glucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) in such patients. (18)F-FDG PET/CT can play an important role in the management of generalized lymphadenopathy. It can help in making an etiological diagnosis; can detect extranodal sites of involvement and employed for monitoring response to therapy.

Citing Articles

Interference of COVID-19 Vaccination With PET/CT Leads to Unnecessary Additional Imaging in a Patient With Metastatic Cutaneous Melanoma-Case Report.

Czepczynski R, Szczurek J, Mackiewicz J, Ruchala M Front Oncol. 2021; 11:690443.

PMID: 34414110 PMC: 8369477. DOI: 10.3389/fonc.2021.690443.

References

Karunanithi S, Singh H, Sharma P, Naswa N, Kumar R . 18F-FDG PET/CT imaging features of Rosai Dorfman disease: a rare cause of massive generalized lymphadenopathy. Clin Nucl Med. 2013; 39(3):268-9. DOI: 10.1097/RLU.0b013e31828731da. View

Perlman D, DAmico R, Salomon N . Mycobacterial Infections of the Head and Neck. Curr Infect Dis Rep. 2001; 3(3):233-241. DOI: 10.1007/s11908-001-0025-4. View

Joshi P, Lele V . Prostatic Adenocarcinoma Masquerading as Generalized lymphadenopathy and Mimicking lymphoma on FDG PET/CT: Diagnosis, Staging, and Evaluation of Therapy Response by FDG PET/CT. Nephrourol Mon. 2013; 4(2):482-4. PMC: 3614268. DOI: 10.5812/numonthly.2303. View

de Leval L, Gisselbrecht C, Gaulard P . Advances in the understanding and management of angioimmunoblastic T-cell lymphoma. Br J Haematol. 2009; 148(5):673-89. DOI: 10.1111/j.1365-2141.2009.08003.x. View

Omur O, Baran Y, Oral A, Ceylan Y . Fluorine-18 fluorodeoxyglucose PET-CT for extranodal staging of non-Hodgkin and Hodgkin lymphoma. Diagn Interv Radiol. 2014; 20(2):185-92. PMC: 4463307. DOI: 10.5152/dir.2013.13174. View

Yuen A, Kamel O, Halpern J, Horning S . Long-term survival after histologic transformation of low-grade follicular lymphoma. J Clin Oncol. 1995; 13(7):1726-33. DOI: 10.1200/JCO.1995.13.7.1726. View

Amrikachi M, Krishnan B, Finch C, Shahab I . Actinomyces and actinobacillus actinomycetemcomitans-Actinomyces-associated lymphadenopathy mimicking lymphoma. Arch Pathol Lab Med. 2000; 124(10):1502-5. DOI: 10.5858/2000-124-1502-AAAAAA. View

Jain V, Hasselquist S, Delaney M . PET scanning in sarcoidosis. Ann N Y Acad Sci. 2011; 1228:46-58. DOI: 10.1111/j.1749-6632.2011.06075.x. View

Aide N, Allouache D, Ollivier Y, De Raucourt S, Switsers O, Bardet S . Early 2'-deoxy-2'-[18F]fluoro-D-glucose PET metabolic response after corticosteroid therapy to differentiate cancer from sarcoidosis and sarcoid-like lesions. Mol Imaging Biol. 2009; 11(4):224-8. DOI: 10.1007/s11307-008-0191-y. View

10.

Barrington S, Mikhaeel N . When should FDG-PET be used in the modern management of lymphoma?. Br J Haematol. 2013; 164(3):315-28. DOI: 10.1111/bjh.12601. View

11.

Bartlett A, Rivera A, Krishnamurthy R, Baker C . Thoracic actinomycosis in children: case report and review of the literature. Pediatr Infect Dis J. 2008; 27(2):165-9. DOI: 10.1097/INF.0b013e3181598353. View

12.

Perera A, Keleher A, Nath M . Rosai-Dorfman disease presenting as a male breast mass. Am Surg. 2007; 73(3):294-5. View

13.

Antonello V, Zaltron V, Vial M, Oliveira F, Severo L . Oropharyngeal histoplasmosis: report of eleven cases and review of the literature. Rev Soc Bras Med Trop. 2011; 44(1):26-9. DOI: 10.1590/s0037-86822011000100007. View

14.

Weiler-Sagie M, Bushelev O, Epelbaum R, Dann E, Haim N, Avivi I . (18)F-FDG avidity in lymphoma readdressed: a study of 766 patients. J Nucl Med. 2009; 51(1):25-30. DOI: 10.2967/jnumed.109.067892. View

15.

LUKES R, Tindle B . Immunoblastic lymphadenopathy. A hyperimmune entity resembling Hodgkin's disease. N Engl J Med. 1975; 292(1):1-8. DOI: 10.1056/NEJM197501022920101. View

16.

Huang J, Lu C, Hsiao C, Tzen K . FDG PET/CT findings in purely cutaneous Rosai-Dorfman disease. Clin Nucl Med. 2011; 36(4):e13-5. DOI: 10.1097/RLU.0b013e31820aa36d. View

17.

Webb W, Sagel S . Actinomycosis involving the chest wall: CT findings. AJR Am J Roentgenol. 1982; 139(5):1007-9. DOI: 10.2214/ajr.139.5.1007. View

18.

Sathekge M, Maes A, Van de Wiele C . FDG-PET imaging in HIV infection and tuberculosis. Semin Nucl Med. 2013; 43(5):349-66. DOI: 10.1053/j.semnuclmed.2013.04.008. View

19.

Mok G, Choi F, Chu W . Actinomycosis imitating parotid cancer with metastatic lymph nodes in FDG PET/CT. Clin Nucl Med. 2011; 36(4):309-10. DOI: 10.1097/RLU.0b013e31820a9fbf. View

20.

Conte M, Bowen D, Wiseman G, Rabe K, Slager S, Schwager S . Use of positron emission tomography-computed tomography in the management of patients with chronic lymphocytic leukemia/small lymphocytic lymphoma. Leuk Lymphoma. 2013; 55(9):2079-84. PMC: 4419693. DOI: 10.3109/10428194.2013.869801. View