Rubella

Overview

Journal Lancet

Publisher Elsevier

Specialty General Medicine

Date 2015 Jan 12

PMID 25576992

Citations 126

Authors

Nathaniel Lambert

Peter Strebel

Walter Orenstein

Joseph Icenogle

Gregory A Poland

Affiliations

Soon will be listed here.

Abstract

Rubella remains an important pathogen worldwide, with roughly 100,000 cases of congenital rubella syndrome estimated to occur every year. Rubella-containing vaccine is highly effective and safe and, as a result, endemic rubella transmission has been interrupted in the Americas since 2009. Incomplete rubella vaccination programmes result in continued disease transmission, as evidenced by recent large outbreaks in Japan and elsewhere. In this Seminar, we provide present results regarding rubella control, elimination, and eradication policies, and a brief review of new laboratory diagnostics. Additionally, we provide novel information about rubella-containing vaccine immunogenetics and review the emerging evidence of interindividual variability in humoral and cell-mediated innate and adaptive immune responses to rubella-containing vaccine and their association with haplotypes and single-nucleotide polymorphisms across the human genome.

Citing Articles

Seropositive Rubella and Toxoplasmosis Among Females Attending Saudi Hospital.

Alhussainy N, Al Braikan F J Trop Med. 2025; 2025:4201991.

PMID: 39981194 PMC: 11842137. DOI: 10.1155/jotm/4201991.

Impact of Immunization Strategies on Rubella Incidence During Progress Toward Rubella Control and Elimination - China, 2004-2023.

Liu S, Xu X, Liu Q, Tang L, Wang X, Huang A China CDC Wkly. 2024; 6(50):1319-1324.

PMID: 39734787 PMC: 11673184. DOI: 10.46234/ccdcw2024.262.

Rubella antibody levels in the healthy Chinese population: a meta-analysis.

Zhuo Y, Lu Z, Zhang X, Zhang X, Yang Y, Han J Front Immunol. 2024; 15:1472189.

PMID: 39600703 PMC: 11590121. DOI: 10.3389/fimmu.2024.1472189.

Congenital and Perinatal Viral Infections: Consequences for the Mother and Fetus.

Al Beloushi M, Saleh H, Ahmed B, Konje J Viruses. 2024; 16(11).

PMID: 39599813 PMC: 11599085. DOI: 10.3390/v16111698.

Rubella myopericarditis and cardiac tamponade: a case report.

Ishibashi Y, Nojiri Y, Takahashi Y, Takahashi S, Fukuda N, Hiroi S Oxf Med Case Reports. 2024; 2024(11):omae130.

PMID: 39575091 PMC: 11576551. DOI: 10.1093/omcr/omae130.

References

PRECHTL H . The organization of behavioral states and their dysfunction. Semin Perinatol. 1992; 16(4):258-63. View

Ou D, Mitchell L, Ho M, Dcarie D, Tingle A, Nepom G . Analysis of overlapping T- and B-cell antigenic sites on rubella virus E1 envelope protein. Influence of HLA-DR4 polymorphism on T-cell clonal recognition. Hum Immunol. 1994; 39(3):177-87. PMC: 7135096. DOI: 10.1016/0198-8859(94)90258-5. View

OShea S, Woodward S, Best J, Banatvala J, Holzel H, DUDGEON J . Rubella vaccination: persistence of antibodies for 10-21 years. Lancet. 1988; 2(8616):909. DOI: 10.1016/s0140-6736(88)92512-3. View

Amanna I, Carlson N, Slifka M . Duration of humoral immunity to common viral and vaccine antigens. N Engl J Med. 2007; 357(19):1903-15. DOI: 10.1056/NEJMoa066092. View

Zrein M, Joncas J, Pedneault L, Robillard L, Dwyer R, Lacroix M . Comparison of a whole-virus enzyme immunoassay (EIA) with a peptide-based EIA for detecting rubella virus immunoglobulin G antibodies following rubella vaccination. J Clin Microbiol. 1993; 31(6):1521-4. PMC: 265571. DOI: 10.1128/jcm.31.6.1521-1524.1993. View

Cordoba P, Lanoel A, Grutadauria S, Zapata M . Evaluation of antibodies against a rubella virus neutralizing domain for determination of immune status. Clin Diagn Lab Immunol. 2000; 7(6):964-6. PMC: 95994. DOI: 10.1128/CDLI.7.6.964-966.2000. View

Haralambieva I, Oberg A, Ovsyannikova I, Kennedy R, Grill D, Middha S . Genome-wide characterization of transcriptional patterns in high and low antibody responders to rubella vaccination. PLoS One. 2013; 8(5):e62149. PMC: 3641062. DOI: 10.1371/journal.pone.0062149. View

Ou D, Mitchell L, Decarie D, Tingle A, Nepom G . Promiscuous T-cell recognition of a rubella capsid protein epitope restricted by DRB1*0403 and DRB1*0901 molecules sharing an HLA DR supertype. Hum Immunol. 1998; 59(3):149-57. DOI: 10.1016/s0198-8859(98)00006-8. View

Poland G, Ovsyannikova I, Jacobson R, Smith D . Heterogeneity in vaccine immune response: the role of immunogenetics and the emerging field of vaccinomics. Clin Pharmacol Ther. 2007; 82(6):653-64. DOI: 10.1038/sj.clpt.6100415. View

10.

Manikkavasagan G, Bukasa A, Brown K, Cohen B, Ramsay M . Oral fluid testing during 10 years of rubella elimination, England and Wales. Emerg Infect Dis. 2010; 16(10):1532-8. PMC: 3294398. DOI: 10.3201/eid1610.100560. View

11.

Suzuki J, Goto H, Komase K, Abo H, Fujii K, Otsuki N . Rubella virus as a possible etiological agent of Fuchs heterochromic iridocyclitis. Graefes Arch Clin Exp Ophthalmol. 2010; 248(10):1487-91. DOI: 10.1007/s00417-010-1434-6. View

12.

Mitchell L, Tingle A, MacWilliam L, Horne C, Keown P, Gaur L . HLA-DR class II associations with rubella vaccine-induced joint manifestations. J Infect Dis. 1998; 177(1):5-12. DOI: 10.1086/513807. View

13.

Goodson J, Masresha B, Dosseh A, Byabamazima C, Nshimirimana D, Cochi S . Rubella epidemiology in Africa in the prevaccine era, 2002-2009. J Infect Dis. 2011; 204 Suppl 1:S215-25. DOI: 10.1093/infdis/jir108. View

14.

Abernathy E, Cabezas C, Sun H, Zheng Q, Chen M, Castillo-Solorzano C . Confirmation of rubella within 4 days of rash onset: comparison of rubella virus RNA detection in oral fluid with immunoglobulin M detection in serum or oral fluid. J Clin Microbiol. 2008; 47(1):182-8. PMC: 2620850. DOI: 10.1128/JCM.01231-08. View

15.

. Rubella virus nomenclature update: 2013. Wkly Epidemiol Rec. 2013; 88(32):337-43. View

16.

Banatvala J, Brown D . Rubella. Lancet. 2004; 363(9415):1127-37. DOI: 10.1016/S0140-6736(04)15897-2. View

17.

Ginsberg-Fellner F, Witt M, Yagihashi S, Dobersen M, TAUB F, Fedun B . Congenital rubella syndrome as a model for type 1 (insulin-dependent) diabetes mellitus: increased prevalence of islet cell surface antibodies. Diabetologia. 1984; 27 Suppl:87-9. DOI: 10.1007/BF00275655. View

18.

Mitchell L, Zhang T, Ho M, Decarie D, Tingle A, Zrein M . Characterization of rubella virus-specific antibody responses by using a new synthetic peptide-based enzyme-linked immunosorbent assay. J Clin Microbiol. 1992; 30(7):1841-7. PMC: 265391. DOI: 10.1128/jcm.30.7.1841-1847.1992. View

19.

Plotkin S, FARQUHAR J, Ogra P . Immunologic properties of RA27-3 rubella virus vaccine. A comparison with strains presently licensed in the United States. JAMA. 1973; 225(6):585-90. DOI: 10.1001/jama.225.6.585. View

20.

Janta D, Stanescu A, Lupulescu E, Molnar G, Pistol A . Ongoing rubella outbreak among adolescents in Salaj, Romania, September 2011-January 2012. Euro Surveill. 2012; 17(7). View