Involvement of RalB in the Effect of Geranylgeranyltransferase I on Glioma Cell Migration and Invasion

Overview

Journal Clin Transl Oncol

Specialty Oncology

Date 2015 Jan 10

PMID 25573158

Citations 3

Authors

X Song

L Hua

Y Xu

Z Fang

Y Wang

J Gao

Q Shi

X Zhou

R Yu

Affiliations

Soon will be listed here.

Abstract

Purpose: The present study aimed at investigating the role and potential mechanism of geranylgeranyltransferase I (GGTase-I) on glioma cell migration and invasion.

Methods: Wound-healing assay and transwell assay were performed to study whether GGTase-I and Ras-like GTPase B (RalB) have effect on glioma cell migration and invasion.

Results: We found that knockdown of GGTase-I or RalB both significantly decreased the migratory and invasive abilities of glioma cells. GGTase-I down-regulation suppressed RalB membrane association. Moreover, down-regulation of RalB partially abolished the effect of GGTβ over-expression-induced glioma cell migration and invasion increase.

Conclusions: These findings suggest that RalB might be one of the targets for facilitating the invasive phenotype of malignant gliomas induced by GGTase-I.

Citing Articles

Antitumor Effects of Ral-GTPases Downregulation in Glioblastoma.

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RAL GTPases: Biology and Potential as Therapeutic Targets in Cancer.

Yan C, Theodorescu D Pharmacol Rev. 2017; 70(1):1-11.

PMID: 29196555 PMC: 5712631. DOI: 10.1124/pr.117.014415.

The Role of Geranylgeranyltransferase I-Mediated Protein Prenylation in the Brain.

Gao S, Yu R, Zhou X Mol Neurobiol. 2015; 53(10):6925-6937.

PMID: 26666664 DOI: 10.1007/s12035-015-9594-3.

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