Use of Umbilical Cord Serum in Ophthalmology

Overview

Journal Chonnam Med J

Specialty General Medicine

Date 2015 Jan 9

PMID 25568842

Citations 26

Authors

Kyung Chul Yoon

Affiliations

Soon will be listed here.

Abstract

Among blood preparations, serum has been topically used in the management of various ocular diseases in ophthalmology. Like peripheral blood serum, umbilical cord blood serum contains a high concentration of essential tear components, growth factors, neurotrophic factors, vitamin A, fibronectin, prealbumin, and oil. Umbilical cord serum can provide basic nutrients for epithelial renewal and can facilitate the proliferation, migration, and differentiation of the ocular surface epithelium. Eye drops made from umbilical cord serum have been applied to treat various ocular surface diseases, including severe dry eye with or without Sjögren's syndrome, ocular complications in graft-versus-host disease, persistent epithelial defects, neurotrophic keratopathy, recurrent corneal erosions, ocular chemical burn, and surface problems after corneal refractive surgery. Because mesenchymal stem cells from umbilical cord blood can be used to regenerate corneal tissue and retinal nerve cells, umbilical cord serum might be applied for tissue engineering and regenerative medicine in the future.

Citing Articles

Blood component therapy for dry eye disease: a systematic review and network meta-analysis.

Zhang Y, Li N, Ge Z, Li F Front Med (Lausanne). 2024; 11:1500160.

PMID: 39736981 PMC: 11683103. DOI: 10.3389/fmed.2024.1500160.

Umbilical Cord Blood-Derived Products in Autoimmune Systemic Syndromes with Severe Dryness: A Pilot Study.

Foti R, Zeppieri M, Foti R, Bosco Y, Foti R, Maniaci A Medicina (Kaunas). 2024; 60(11).

PMID: 39596949 PMC: 11596058. DOI: 10.3390/medicina60111764.

Blood-Derived Eye Drops for the Treatment of Corneal Neuropathic Pain.

Anam A, Liu C, Tong L, Liu Y J Ocul Pharmacol Ther. 2024; 40(5):281-292.

PMID: 38648544 PMC: 11296151. DOI: 10.1089/jop.2023.0155.

New advances in medical management of dry eye: optimizing treatment strategies for enhanced relief.

Shahraki T, Baradaran-Rafii A, Ayyala R, Arabi A, Jarstad J, Memar F Int Ophthalmol. 2024; 44(1):49.

PMID: 38337030 DOI: 10.1007/s10792-024-02978-1.

Current Advances in Regenerative Strategies for Dry Eye Diseases: A Comprehensive Review.

Bhujel B, Oh S, Kim C, Yoon Y, Chung H, Ye E Bioengineering (Basel). 2024; 11(1).

PMID: 38247916 PMC: 10813666. DOI: 10.3390/bioengineering11010039.

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