Oral Signs of Acute Leukemia for Early Detection

Overview

Journal J Periodontal Implant Sci

Specialty Dentistry

Date 2015 Jan 9

PMID 25568810

Citations 11

Authors

Hyun-Chang Lim

Chang-Sung Kim

Affiliations

Soon will be listed here.

Abstract

Purpose: Systemic disease can manifest oral signs at an early phase, which may be crucial for the diagnosis and timing of treatment. This report describes two patients who presented with gingival enlargement as an early sign of acute leukemia.

Methods: Two patients presented with oral symptoms including severe gingival enlargement. The progress of their symptoms was associated with underlying systemic disease.

Results: The patients were transferred to the Department of Hematology and diagnosed with acute myelomonocytic leukemia. They received appropriate treatment and survived.

Conclusions: Gingival enlargement can be caused by underlying systemic diseases. Accurate diagnosis and timely referral are important for preventing a fatal situation. It must be emphasized that some oral signs and symptoms may be closely correlated with systemic diseases.

Citing Articles

Challenges in Differential Diagnosis of Diffuse Gingival Enlargement: Report of Two Representative Cases and Literature Review.

Papadopoulou E, Kouri M, Andreou A, Diamanti S, Georgaki M, Katoumas K Dent J (Basel). 2024; 12(12).

PMID: 39727460 PMC: 11674662. DOI: 10.3390/dj12120403.

Different Levels of Therapeutic Strategies to Recover the Microbiome to Prevent/Delay Acute Lymphoblastic Leukemia (ALL) or Arrest Its Progression in Children.

Aronica T, Carella M, Balistreri C Int J Mol Sci. 2024; 25(7).

PMID: 38612738 PMC: 11012256. DOI: 10.3390/ijms25073928.

Delayed diagnosis of advanced stage Leukemia in Two Pediatric Patients with Oral Manifestation.

Gangwar A J Clin Exp Dent. 2024; 15(12):e1060-e1063.

PMID: 38186914 PMC: 10767738. DOI: 10.4317/jced.61067.

Oral Manifestations: A Warning-Sign in Children with Hematological Disease Acute Lymphocytic Leukemia.

Soares S, Roux L, Castro A, Silva C, Rodrigues R, Macho V Hematol Rep. 2023; 15(3):491-502.

PMID: 37754666 PMC: 10530953. DOI: 10.3390/hematolrep15030051.

Oral manifestations of leukemia as part of early diagnosis.

Quispe R, Aguiar E, de Oliveira C, Neves A, Santos P Hematol Transfus Cell Ther. 2021; 44(3):392-401.

PMID: 34862157 PMC: 9477758. DOI: 10.1016/j.htct.2021.08.006.

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