First Case of Disseminated Infection with Nocardia Cerradoensis in a Human

Overview

Journal J Clin Microbiol

Specialty Microbiology

Date 2015 Jan 9

PMID 25568436

Citations 12

Authors

Caroline Piau

Mallorie Kerjouan

Marc Le Mouel

Solene Patrat-Delon

Pierre-Louis Henaux

Vanessa Brun

Marie-Pascale Morin

Philippe Gautier

Veronica Rodriguez-Nava

Samer Kayal

Affiliations

Soon will be listed here.

Abstract

Here we report in a human, a renal transplant patient, the first disseminated infection with Nocardia cerradoensis, isolated after a brain biopsy. Species identification was based on 16S rRNA, gyrB, and hsp65 gene analyses. Antibiotic treatment was successful by combining carbapenems and aminoglycosides and then switching to oral trimethoprim-sulfamethoxazole.

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References

Albuquerque de Barros E, Manfio G, Maitan V, Mendes Bataus L, Kim S, Maldonado L . Nocardia cerradoensis sp. nov., a novel isolate from Cerrado soil in Brazil. Int J Syst Evol Microbiol. 2003; 53(Pt 1):29-33. DOI: 10.1099/ijs.0.02020-0. View

Mamelak A, Obana W, Flaherty J, Rosenblum M . Nocardial brain abscess: treatment strategies and factors influencing outcome. Neurosurgery. 1994; 35(4):622-31. DOI: 10.1227/00006123-199410000-00007. View

Rich J, Sullivan T, Greineder D, Kazanjian P . Trimethoprim/sulfamethoxazole incremental dose regimen in human immunodeficiency virus-infected persons. Ann Allergy Asthma Immunol. 1997; 79(5):409-14. DOI: 10.1016/S1081-1206(10)63034-7. View

Rodriguez-Nava V, Couble A, Devulder G, Flandrois J, Boiron P, Laurent F . Use of PCR-restriction enzyme pattern analysis and sequencing database for hsp65 gene-based identification of Nocardia species. J Clin Microbiol. 2006; 44(2):536-46. PMC: 1392680. DOI: 10.1128/JCM.44.2.536-546.2006. View

George S, Rivera A, Hsu S . Disseminated cutaneous nocardiosis mimicking cellulitis and erythema nodosum. Dermatol Online J. 2007; 12(7):13. View

Takeda K, Kang Y, Yazawa K, Gonoi T, Mikami Y . Phylogenetic studies of Nocardia species based on gyrB gene analyses. J Med Microbiol. 2009; 59(Pt 2):165-171. DOI: 10.1099/jmm.0.011346-0. View

Ambrosioni J, Lew D, Garbino J . Nocardiosis: updated clinical review and experience at a tertiary center. Infection. 2010; 38(2):89-97. DOI: 10.1007/s15010-009-9193-9. View

Tripodi M, Durante-Mangoni E, Fortunato R, Cuccurullo S, Mikami Y, Farina C . In vitro activity of multiple antibiotic combinations against Nocardia: relationship with a short-term treatment strategy in heart transplant recipients with pulmonary nocardiosis. Transpl Infect Dis. 2010; 13(4):335-43. DOI: 10.1111/j.1399-3062.2010.00588.x. View

Yu X, Han F, Wu J, He Q, Peng W, Wang Y . Nocardia infection in kidney transplant recipients: case report and analysis of 66 published cases. Transpl Infect Dis. 2011; 13(4):385-91. DOI: 10.1111/j.1399-3062.2011.00607.x. View

10.

Santos M, Gil-Brusola A, Morales P . Infection by Nocardia in solid organ transplantation: thirty years of experience. Transplant Proc. 2011; 43(6):2141-4. DOI: 10.1016/j.transproceed.2011.06.065. View

11.

Wilson J . Nocardiosis: updates and clinical overview. Mayo Clin Proc. 2012; 87(4):403-7. PMC: 3498414. DOI: 10.1016/j.mayocp.2011.11.016. View

12.

Flateau C, Jurado V, Lemaitre N, Loiez C, Wallet F, Saiz-Jimenez C . First case of cerebral abscess due to a novel Nocardia species in an immunocompromised patient. J Clin Microbiol. 2012; 51(2):696-700. PMC: 3553903. DOI: 10.1128/JCM.00762-12. View

13.

Schlaberg R, Fisher M, Hanson K . Susceptibility profiles of Nocardia isolates based on current taxonomy. Antimicrob Agents Chemother. 2013; 58(2):795-800. PMC: 3910866. DOI: 10.1128/AAC.01531-13. View

14.

Lebeaux D, Morelon E, Suarez F, Lanternier F, Scemla A, Frange P . Nocardiosis in transplant recipients. Eur J Clin Microbiol Infect Dis. 2013; 33(5):689-702. DOI: 10.1007/s10096-013-2015-5. View

15.

Larruskain J, Idigoras P, Marimon J, Perez-Trallero E . Susceptibility of 186 Nocardia sp. isolates to 20 antimicrobial agents. Antimicrob Agents Chemother. 2011; 55(6):2995-8. PMC: 3101401. DOI: 10.1128/AAC.01279-10. View