(18)F-FDG PET/CT in Patients with Nodular Pulmonary Amyloidosis: Case Report and Literature Review

Overview

Journal Case Rep Oncol

Publisher Karger

Specialty Oncology

Date 2015 Jan 8

PMID 25566054

Citations 1

Authors

Xiao-Qing Quan

Tie-Jun Yin

Cun-Tai Zhang

Jian Liu

Li-Fen Qiao

Chang-Shu Ke

Affiliations

Soon will be listed here.

Abstract

A 62-year-old woman was found to have multiple bilateral pulmonary nodules showing different (18)F-fluorodeoxyglucose (FDG) uptakes on positron-emission tomography/computed tomography (PET/CT). Only the largest nodule in the left lower lobe showed an increased (18)F-FDG uptake on PET/CT. Three nodules were surgically resected from different lobes of the left lung. Two lobes were benign and showed amyloid deposition. The largest nodule in the left lower lobe showed adenocarcinoma and a heavy amyloid deposition. Pulmonary amyloidosis should be added to the differential diagnosis for cases with multiple pulmonary nodules that show different (18)F-FDG uptakes on PET/CT. To the best of our knowledge, this is the second reported case of a lung nodule consisting of adenocarcinoma and amyloid deposition.

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Uncommon Presentation of Undiagnosed B-Cell Lymphoproliferative Disorder as Nodular Pulmonary Amyloidosis.

Patel H, Sheikh A, Medarametla G, Selvam S, Mahmood S, Johal G J Med Cases. 2023; 14(1):36-43.

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References

Simsek Z, Oymak F, Tutar N, Canoz O, Demir R . A Rare Cause of Diffuse Parenchymal Lung Disease together with Granulomatous Reaction: Pulmonary Amyloidosis. Case Rep Pulmonol. 2013; 2013:837190. PMC: 3600268. DOI: 10.1155/2013/837190. View

Seo J, Lee S, Ahn B, Lee J . Pulmonary amyloidosis mimicking multiple metastatic lesions on F-18 FDG PET/CT. Lung Cancer. 2009; 67(3):376-9. DOI: 10.1016/j.lungcan.2009.11.014. View

Yadav S, Sharma S, Gilfillan I . Unusual positron emission tomography findings in pulmonary amyloidosis: a case report. J Cardiothorac Surg. 2006; 1:32. PMC: 1617090. DOI: 10.1186/1749-8090-1-32. View

Yamauchi M, Shinozaki K, Doi M, Nitta T, Nishisaka T . A Case of Gingival Metastasis from Rectal Cancer in Which Immunohistochemistry and PET-CT Were Useful for the Diagnostic Procedure. Case Rep Oncol. 2014; 7(1):246-51. PMC: 3999573. DOI: 10.1159/000362185. View

Ollenberger G, Knight S, Tauro A . False-positive FDG positron emission tomography in pulmonary amyloidosis. Clin Nucl Med. 2004; 29(10):657-8. DOI: 10.1097/00003072-200410000-00018. View

Tan H, Guan Y, Zhao J, Lin X . Findings of pulmonary amyloidosis on dual phase FDG PET/CT imaging. Clin Nucl Med. 2010; 35(3):206-7. DOI: 10.1097/RLU.0b013e3181cc64b5. View

Miyazaki D, Yazaki M, Ishii W, Matsuda M, Hoshii Y, Nara K . A rare lung nodule consisting of adenocarcinoma and amyloid deposition in a patient with primary systemic AL amyloidosis. Intern Med. 2011; 50(3):243-6. DOI: 10.2169/internalmedicine.50.4094. View

Hoffmann M, Wohrer S, Becherer A, Chott A, Streubel B, Kletter K . 18F-Fluoro-deoxy-glucose positron emission tomography in lymphoma of mucosa-associated lymphoid tissue: histology makes the difference. Ann Oncol. 2006; 17(12):1761-5. DOI: 10.1093/annonc/mdl295. View

Williams A, Gutzeit A, Germer M, Pless M . PET-Negative Gastrointestinal Stromal Tumors. Case Rep Oncol. 2014; 6(3):508-13. PMC: 3884209. DOI: 10.1159/000355432. View

10.

Mukherjee A, Dhull V, Sharma P, Parida G, Jain S, Pal L . Pulmonary amyloidosis in a patient with Langerhans cell histiocytosis: diagnostic dilemma on 18F-FDG PET/CT. Clin Nucl Med. 2013; 39(4):e263-4. DOI: 10.1097/RLU.0b013e3182a7556d. View

11.

Zhang L, Xue X, Wang N, Wang J . Mimicking pulmonary multiple metastatic tumors: A case of primary nodular parenchymal pulmonary amyloidosis with review of the literature. Oncol Lett. 2012; 4(6):1366-1370. PMC: 3506749. DOI: 10.3892/ol.2012.923. View

12.

Jeong S, Lee K, Shin K, Bae Y, Kim B, Choe B . Efficacy of PET/CT in the characterization of solid or partly solid solitary pulmonary nodules. Lung Cancer. 2008; 61(2):186-94. DOI: 10.1016/j.lungcan.2007.12.021. View

13.

Quaia E, Tona G, Gelain F, Lubin E, Pizzolato R, Boscolo E . Integrated fluorine-18 fluorodeoxyglucose (18F-FDG) PET/CT compared to standard contrast-enhanced CT for characterization and staging of pulmonary tumors eligible for surgical resection. Acta Radiol. 2008; 49(9):995-1004. DOI: 10.1080/02841850802291259. View

14.

Lachmann H, Hawkins P . Amyloidosis and the lung. Chron Respir Dis. 2006; 3(4):203-14. DOI: 10.1177/1479972306070066. View

15.

Van Nostrand W, Melchor J, Ruffini L . Pathologic amyloid beta-protein cell surface fibril assembly on cultured human cerebrovascular smooth muscle cells. J Neurochem. 1998; 70(1):216-23. DOI: 10.1046/j.1471-4159.1998.70010216.x. View

16.

Gould M, Maclean C, Kuschner W, Rydzak C, Owens D . Accuracy of positron emission tomography for diagnosis of pulmonary nodules and mass lesions: a meta-analysis. JAMA. 2001; 285(7):914-24. DOI: 10.1001/jama.285.7.914. View

17.

Mekinian A, Jaccard A, Soussan M, Launay D, Berthier S, Federici L . 18F-FDG PET/CT in patients with amyloid light-chain amyloidosis: case-series and literature review. Amyloid. 2012; 19(2):94-8. DOI: 10.3109/13506129.2012.682833. View

18.

Grubstein A, Shitrit D, Sapir E, Cohen M, Kramer M . Pulmonary amyloidosis: detection with PET-CT. Clin Nucl Med. 2005; 30(6):420-1. DOI: 10.1097/01.rlu.0000162965.38269.3c. View

19.

Kumaran R, Saleh A, Amin B, Raoof S . A 73-year-old woman with mild shortness of breath and multiple central calcified pulmonary nodules. Chest. 2008; 134(2):460-464. DOI: 10.1378/chest.07-1955. View

20.

Currie G, Rossiter C, Dempsey O, Legge J . Pulmonary amyloid and PET scanning. Respir Med. 2005; 99(11):1463-4. DOI: 10.1016/j.rmed.2005.04.030. View