Are the Effects of Duration of Untreated Psychosis Socially Mediated?

Overview

Journal Can J Psychiatry

Specialty Psychiatry

Date 2015 Jan 8

PMID 25565684

Citations 3

Authors

Ross M G Norman

Affiliations

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Abstract

Investigation of possible mechanisms by which longer duration of untreated psychosis (DUP) could influence treatment outcomes has focused primarily on evidence for neurotoxic effects. It is also possible that longer DUP has psychosocial effects, which could mediate its impact on outcomes. The evidence of relevance to such socially toxic effects is reviewed, with particular reference to the possible role of social support. There is no definite evidence for social support as a mediator of the influence of DUP, but further investigation of this issue is warranted.

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References

Davis L, Kurzban S, Brekke J . Self-esteem as a mediator of the relationship between role functioning and symptoms for individuals with severe mental illness: a prospective analysis of Modified Labeling theory. Schizophr Res. 2012; 137(1-3):185-9. DOI: 10.1016/j.schres.2012.02.003. View

Perkins D, Gu H, Boteva K, Lieberman J . Relationship between duration of untreated psychosis and outcome in first-episode schizophrenia: a critical review and meta-analysis. Am J Psychiatry. 2005; 162(10):1785-804. DOI: 10.1176/appi.ajp.162.10.1785. View

Wyatt R . Neuroleptics and the natural course of schizophrenia. Schizophr Bull. 1991; 17(2):325-51. DOI: 10.1093/schbul/17.2.325. View

Agarkar S . A case of prolonged duration of untreated psychosis: barriers to treatment and strategies to improve the outcome. Clin Schizophr Relat Psychoses. 2012; 6(1):45-8. DOI: 10.3371/CSRP.6.1.6. View

Thomas S, Nandhra H . Early intervention in psychosis: a retrospective analysis of clinical and social factors influencing duration of untreated psychosis. Prim Care Companion J Clin Psychiatry. 2009; 11(5):212-4. PMC: 2781032. DOI: 10.4088/PCC.08m00705. View

OCallaghan E, Turner N, Renwick L, Jackson D, Sutton M, Foley S . First episode psychosis and the trail to secondary care: help-seeking and health-system delays. Soc Psychiatry Psychiatr Epidemiol. 2009; 45(3):381-91. DOI: 10.1007/s00127-009-0081-x. View

Garety P, Kuipers E, Fowler D, Freeman D, Bebbington P . A cognitive model of the positive symptoms of psychosis. Psychol Med. 2001; 31(2):189-95. DOI: 10.1017/s0033291701003312. View

Windell D, Norman R . A qualitative analysis of influences on recovery following a first episode of psychosis. Int J Soc Psychiatry. 2012; 59(5):493-500. DOI: 10.1177/0020764012443751. View

Bebbington P, Kuipers L . The predictive utility of expressed emotion in schizophrenia: an aggregate analysis. Psychol Med. 1994; 24(3):707-18. DOI: 10.1017/s0033291700027860. View

10.

Lloyd C, King R, Moore L . Subjective and objective indicators of recovery in severe mental illness: a cross-sectional study. Int J Soc Psychiatry. 2009; 56(3):220-9. DOI: 10.1177/0020764009105703. View

11.

Tempier R, Balbuena L, Garety P, Craig T . Does assertive community outreach improve social support? Results from the Lambeth Study of early-episode psychosis. Psychiatr Serv. 2012; 63(3):216-22. DOI: 10.1176/appi.ps.20110013. View

12.

Uchino B . Understanding the Links Between Social Support and Physical Health: A Life-Span Perspective With Emphasis on the Separability of Perceived and Received Support. Perspect Psychol Sci. 2015; 4(3):236-55. DOI: 10.1111/j.1745-6924.2009.01122.x. View

13.

Lincoln C, Harrigan S, McGorry P . Understanding the topography of the early psychosis pathways. An opportunity to reduce delays in treatment. Br J Psychiatry Suppl. 1998; 172(33):21-5. View

14.

McGlashan T . Is active psychosis neurotoxic?. Schizophr Bull. 2006; 32(4):609-13. PMC: 2632265. DOI: 10.1093/schbul/sbl032. View

15.

Lihong Q, Shimodera S, Fujita H, Morokuma I, Nishida A, Kamimura N . Duration of untreated psychosis in a rural/suburban region of Japan. Early Interv Psychiatry. 2012; 6(3):239-46. DOI: 10.1111/j.1751-7893.2011.00325.x. View

16.

Lappin J, Morgan K, Morgan C, Dazzan P, Reichenberg A, Zanelli J . Duration of untreated psychosis and neuropsychological function in first episode psychosis. Schizophr Res. 2007; 95(1-3):103-10. DOI: 10.1016/j.schres.2007.05.037. View

17.

DeVylder J, Gearing R . Declining social support in adolescents prior to first episode psychosis: associations with negative and affective symptoms. Psychiatry Res. 2013; 210(1):50-4. DOI: 10.1016/j.psychres.2013.02.004. View

18.

Haber M, Cohen J, Lucas T, Baltes B . The relationship between self-reported received and perceived social support: a meta-analytic review. Am J Community Psychol. 2007; 39(1-2):133-44. DOI: 10.1007/s10464-007-9100-9. View

19.

Norman R, Windell D, Lynch J, Manchanda R . Perceived relational evaluation as a predictor of self-esteem and mood in people with a psychotic disorder. Can J Psychiatry. 2012; 57(5):309-16. DOI: 10.1177/070674371205700506. View

20.

Johnstone E, Crow T, Johnson A, Macmillan J . The Northwick Park Study of first episodes of schizophrenia. I. Presentation of the illness and problems relating to admission. Br J Psychiatry. 1986; 148:115-20. DOI: 10.1192/bjp.148.2.115. View