The Influence of the Microbiota on the Immune Response to Transplantation

Overview

Journal Curr Opin Organ Transplant

Specialty General Surgery

Date 2015 Jan 8

PMID 25563985

Citations 10

Authors

Caroline Bartman

Anita S Chong

Maria-Luisa Alegre

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: In the past decade, appreciation of the important effects of commensal microbes on immunity has grown exponentially. The effect of the microbiota on transplantation has only recently begun to be explored; however, our understanding of the mechanistic details of host-microbe interactions is still lacking.

Recent Findings: It has become clear that transplantation is associated with changes in the microbiota in many different settings, although what clinical events and therapeutic interventions contribute to these changes remains to be parsed out. Research groups have begun to identify associations between specific communities of organisms and transplant outcomes, but it remains to be established whether microbial changes precede or follow transplant rejection episodes. Finally, results from continuing exploration of basic mechanisms by which microbial communities affect innate and adaptive immunity in various animal models of disease continue to inform research on the microbiota's effects on immune responses against transplanted organs.

Summary: Commensal microbes may alter immune responses to organ transplantation, but direct experiments are only beginning in the field to identify species and immune pathways responsible for these putative effects.

Citing Articles

Reduced immunomodulatory metabolite concentrations in peri-transplant fecal samples from heart allograft recipients.

Dela Cruz M, Lin H, Han J, Adler E, Boissiere J, Khalid M Front Transplant. 2024; 2:1182534.

PMID: 38993864 PMC: 11235359. DOI: 10.3389/frtra.2023.1182534.

Pain Interference in End Stage Kidney Disease is Associated with Changes in Gut Microbiome Features Before and After Kidney Transplantation.

Lockwood M, Chlipala G, Maeinschein-Cline M, DeVon H, Lichvar A, Samra M Pain Manag Nurs. 2022; 24(1):68-77.

PMID: 36184305 PMC: 9925398. DOI: 10.1016/j.pmn.2022.08.013.

The Microbiome and Metabolomic Profile of the Transplanted Intestine with Long-Term Function.

Girlanda R, Liggett J, Jayatilake M, Kroemer A, Guerra J, Hawksworth J Biomedicines. 2022; 10(9).

PMID: 36140180 PMC: 9495872. DOI: 10.3390/biomedicines10092079.

Engineering immunomodulatory biomaterials for type 1 diabetes.

Stabler C, Li Y, Stewart J, Keselowsky B Nat Rev Mater. 2020; 4(6):429-450.

PMID: 32617176 PMC: 7332200. DOI: 10.1038/s41578-019-0112-5.

Considerations When Designing a Microbiome Study: Implications for Nursing Science.

Maki K, Diallo A, Lockwood M, Franks A, Green S, Joseph P Biol Res Nurs. 2018; 21(2):125-141.

PMID: 30409024 PMC: 6700895. DOI: 10.1177/1099800418811639.

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