Could GLUT12 Be a Potential Therapeutic Target in Cancer Treatment? A Preliminary Report

Overview

Journal J Cancer

Specialty Oncology

Date 2015 Jan 7

PMID 25561978

Citations 18

Authors

Jonai Pujol-Gimenez

Fatima Perez de Heredia

Miguel Angel Idoate

Rachel Airley

Maria Pilar Lostao

Andrew Robert Evans

Affiliations

Soon will be listed here.

Abstract

Background: Recent studies proposed GLUT12 to be a major glucose transporter involved in the glycolytic metabolism of cancer cells.

Methods: GLUT12 expression was determined by immunohistochemistry in a selection of cancer cell lines and a tumour spheroid model.

Results: GLUT12 expression was high in A549 and RH-36; low in HT29; and absent in NB-EB cancer cell lines. GLUT12 expression was located in the necrotic centre of HT29 spheroids, which is characterised by anaerobic metabolism.

Conclusion: The data supports the involvement of GLUT12 in the glycolytic metabolism of cancer cells and therefore, its potential as a novel therapeutic target for cancer treatment.

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References

Ostergaard L, Tietze A, Nielsen T, Drasbek K, Mouridsen K, Jespersen S . The relationship between tumor blood flow, angiogenesis, tumor hypoxia, and aerobic glycolysis. Cancer Res. 2013; 73(18):5618-24. DOI: 10.1158/0008-5472.CAN-13-0964. View

Pujol-Gimenez J, Barrenetxe J, Gonzalez-Muniesa P, Lostao M . The facilitative glucose transporter GLUT12: what do we know and what would we like to know?. J Physiol Biochem. 2013; 69(2):325-33. DOI: 10.1007/s13105-012-0213-8. View

Godoy A, Ulloa V, Rodriguez F, Reinicke K, Yanez A, Garcia M . Differential subcellular distribution of glucose transporters GLUT1-6 and GLUT9 in human cancer: ultrastructural localization of GLUT1 and GLUT5 in breast tumor tissues. J Cell Physiol. 2006; 207(3):614-27. DOI: 10.1002/jcp.20606. View

Tweddle D, Malcolm A, Cole M, Pearson A, Lunec J . p53 cellular localization and function in neuroblastoma: evidence for defective G(1) arrest despite WAF1 induction in MYCN-amplified cells. Am J Pathol. 2001; 158(6):2067-77. PMC: 1892004. DOI: 10.1016/S0002-9440(10)64678-0. View

Golde D, Concha I, Rivas C, Delgado-Lopez F, Baselga J, Nualart F . Expression of the fructose transporter GLUT5 in human breast cancer. Proc Natl Acad Sci U S A. 1996; 93(5):1847-52. PMC: 39870. DOI: 10.1073/pnas.93.5.1847. View

Noguchi Y, Marat D, Saito A, Yoshikawa T, Doi C, Fukuzawa K . Expression of facilitative glucose transporters in gastric tumors. Hepatogastroenterology. 1999; 46(28):2683-9. View

Uldry M, Thorens B . The SLC2 family of facilitated hexose and polyol transporters. Pflugers Arch. 2003; 447(5):480-9. DOI: 10.1007/s00424-003-1085-0. View

Hirschhaeuser F, Menne H, Dittfeld C, West J, Mueller-Klieser W, Kunz-Schughart L . Multicellular tumor spheroids: an underestimated tool is catching up again. J Biotechnol. 2010; 148(1):3-15. DOI: 10.1016/j.jbiotec.2010.01.012. View

Rogers S, Macheda M, Docherty S, Carty M, Henderson M, Soeller W . Identification of a novel glucose transporter-like protein-GLUT-12. Am J Physiol Endocrinol Metab. 2002; 282(3):E733-8. DOI: 10.1152/ajpendo.2002.282.3.E733. View

10.

Younes M, Lechago L, Somoano J, Mosharaf M, Lechago J . Immunohistochemical detection of Glut3 in human tumors and normal tissues. Anticancer Res. 1997; 17(4A):2747-50. View

11.

Szablewski L . Expression of glucose transporters in cancers. Biochim Biophys Acta. 2012; 1835(2):164-9. DOI: 10.1016/j.bbcan.2012.12.004. View

12.

Airley R, Evans A, Mobasheri A, Hewitt S . Glucose transporter Glut-1 is detectable in peri-necrotic regions in many human tumor types but not normal tissues: Study using tissue microarrays. Ann Anat. 2010; 192(3):133-8. PMC: 7556322. DOI: 10.1016/j.aanat.2010.03.001. View

13.

Suganuma N, Segade F, Matsuzu K, Bowden D . Differential expression of facilitative glucose transporters in normal and tumour kidney tissues. BJU Int. 2007; 99(5):1143-9. DOI: 10.1111/j.1464-410X.2007.06765.x. View

14.

Airley R, Phillips R, Evans A, Double J, Burger A, Feibig H . Hypoxia-regulated glucose transporter Glut-1 may influence chemosensitivity to some alkylating agents: results of EORTC (First Translational Award) study of the relevance of tumour hypoxia to the outcome of chemotherapy in human tumour-derived.... Int J Oncol. 2005; 26(6):1477-84. DOI: 10.3892/ijo.26.6.1477. View

15.

Gude N, Stevenson J, Murthi P, Rogers S, Best J, Kalionis B . Expression of GLUT12 in the fetal membranes of the human placenta. Placenta. 2005; 26(1):67-72. DOI: 10.1016/j.placenta.2004.04.006. View

16.

Stockhammer F, von Deimling A, Synowitz M, Blechschmidt C, van Landeghem F . Expression of glucose transporter 1 is associated with loss of heterozygosity of chromosome 1p in oligodendroglial tumors WHO grade II. J Mol Histol. 2008; 39(5):553-60. DOI: 10.1007/s10735-008-9191-0. View

17.

Canner J, Sobo M, Ball S, Hutzen B, DeAngelis S, Willis W . MI-63: a novel small-molecule inhibitor targets MDM2 and induces apoptosis in embryonal and alveolar rhabdomyosarcoma cells with wild-type p53. Br J Cancer. 2009; 101(5):774-81. PMC: 2736841. DOI: 10.1038/sj.bjc.6605199. View

18.

Pujol-Gimenez J, Martisova E, Perez-Mediavilla A, Lostao M, Ramirez M . Expression of the glucose transporter GLUT12 in Alzheimer's disease patients. J Alzheimers Dis. 2014; 42(1):97-101. DOI: 10.3233/JAD-132498. View

19.

Medina R, Owen G . Glucose transporters: expression, regulation and cancer. Biol Res. 2002; 35(1):9-26. DOI: 10.4067/s0716-97602002000100004. View

20.

Gude N, Stevenson J, Rogers S, Best J, Kalionis B, Huisman M . GLUT12 expression in human placenta in first trimester and term. Placenta. 2003; 24(5):566-70. DOI: 10.1053/plac.2002.0925. View