A Matched Case-control Study of Preterm Birth in One Hospital in Beijing, China

Overview

Journal Reprod Health

Publisher Biomed Central

Specialty Reproductive Medicine

Date 2015 Jan 7

PMID 25561377

Citations 6

Authors

Aiqun Huang

Xi Jin

Xiaohong Liu

Suhong Gao

Affiliations

Soon will be listed here.

Abstract

Background: Preterm birth is an unresolved global health issue. The etiologies of preterm birth are complex and multifactorial. To examine risk factors related to preterm birth, a matched case-control study was conducted in a hospital in Beijing, China where little data on preterm birth have been published in the scientific literature.

Methods: A 1:1 matched case-control study was conducted in 172 pairs of women with preterm birth (case group) and term delivery (control group). Eligible subjects were interviewed in person by well-trained investigators using a questionnaire. Information on obstetric diagnosis and newborns were abstracted from inpatients' medical records. Univariate and multivariate conditional logistic regression models were used to measure the associations between related factors and preterm birth.

Results: Univariate analysis showed that 6 of 12 factors were associated with preterm birth. Multivariate results showed that gestational hypertension (OR = 7.76), low gestational weight gain (OR = 3.02), frequent prenatal care (OR = 0.16), balanced diet (OR = 0.36), and high gestational weight gain (OR = 0.41) were associated with preterm birth.

Conclusion: This study provides information on preterm birth in Beijing, China, and it also lends support to existing evidence about the role of maternal nutritional status, prenatal care and gestational hypertension as risk factors for preterm birth.

Citing Articles

Antenatal depression among pregnant women in Ethiopia: An umbrella review.

Abebe M, Asgedom Y, Gebrekidan A, Tebeje T PLoS One. 2025; 20(1):e0315994.

PMID: 39836614 PMC: 11750105. DOI: 10.1371/journal.pone.0315994.

Short-term exposure of 2.4 GHz electromagnetic radiation on cellular ROS generation and apoptosis in SH-SY5Y cell line and impact on developing chick embryo brain tissue.

Deena K, Maadurshni G, Manivannan J, Sivasamy R Mol Biol Rep. 2025; 52(1):144.

PMID: 39836269 DOI: 10.1007/s11033-025-10217-8.

Magnitude and determinants of intimate partner violence against women in Somalia: evidence from the SDHS survey 2020 dataset.

Abokor A, Adam Farih O, Ali M, Chesneau C, Muse A BMC Womens Health. 2025; 25(1):22.

PMID: 39815226 PMC: 11737054. DOI: 10.1186/s12905-024-03539-5.

Trends in the levels, causes, and risk factors of maternal mortality in Pakistan: A comparative analysis of national surveys of 2007 and 2019.

Midhet F, Khalid S, Baqai S, Khan S PLoS One. 2025; 20(1):e0311730.

PMID: 39804883 PMC: 11729956. DOI: 10.1371/journal.pone.0311730.

Risk Factors for Adverse Pregnancy Outcomes among Zhuang Ethnic Pregnant Women: A Cohort Study in Guangxi, China.

Feng B, Peng Y, Liang J, Wu L, Jiang Q, Liu S Curr Med Sci. 2021; 41(2):219-227.

PMID: 33877538 DOI: 10.1007/s11596-021-2339-9.

References

Li S, Xi B . Preterm birth is associated with risk of essential hypertension in later life. Int J Cardiol. 2014; 172(2):e361-3. DOI: 10.1016/j.ijcard.2013.12.300. View

Zhou B . [Predictive values of body mass index and waist circumference to risk factors of related diseases in Chinese adult population]. Zhonghua Liu Xing Bing Xue Za Zhi. 2002; 23(1):5-10. View

Vintzileos A, Ananth C, Smulian J, Scorza W, Knuppel R . The impact of prenatal care in the United States on preterm births in the presence and absence of antenatal high-risk conditions. Am J Obstet Gynecol. 2002; 187(5):1254-7. DOI: 10.1067/mob.2002.127140. View

Xinxo S, Bimbashi A, Z Kakarriqi E, Zaimi E . Association between maternal nutritional status of pre pregnancy, gestational weight gain and preterm birth. Mater Sociomed. 2013; 25(1):6-8. PMC: 3650563. DOI: 10.5455/msm.2013.25.6-8. View

Hendler I, Goldenberg R, Mercer B, Iams J, Meis P, Moawad A . The Preterm Prediction Study: association between maternal body mass index and spontaneous and indicated preterm birth. Am J Obstet Gynecol. 2005; 192(3):882-6. DOI: 10.1016/j.ajog.2004.09.021. View

Morken N . Preterm birth: new data on a global health priority. Lancet. 2012; 379(9832):2128-30. DOI: 10.1016/S0140-6736(12)60857-5. View

Belizan J, Hofmeyr J, Buekens P, Salaria N . Preterm birth, an unresolved issue. Reprod Health. 2013; 10(1):58. PMC: 3842828. DOI: 10.1186/1742-4755-10-58. View

Xiong X, Demianczuk N, Saunders L, Wang F, Fraser W . Impact of preeclampsia and gestational hypertension on birth weight by gestational age. Am J Epidemiol. 2002; 155(3):203-9. DOI: 10.1093/aje/155.3.203. View

McDonald S, Han Z, Mulla S, Beyene J . Overweight and obesity in mothers and risk of preterm birth and low birth weight infants: systematic review and meta-analyses. BMJ. 2010; 341:c3428. PMC: 2907482. DOI: 10.1136/bmj.c3428. View

10.

Simmons L, Rubens C, Darmstadt G, Gravett M . Preventing preterm birth and neonatal mortality: exploring the epidemiology, causes, and interventions. Semin Perinatol. 2010; 34(6):408-15. DOI: 10.1053/j.semperi.2010.09.005. View

11.

Beck S, Wojdyla D, Say L, Betran A, Merialdi M, Requejo J . The worldwide incidence of preterm birth: a systematic review of maternal mortality and morbidity. Bull World Health Organ. 2010; 88(1):31-8. PMC: 2802437. DOI: 10.2471/BLT.08.062554. View

12.

Crump C, Sundquist K, Sundquist J, Winkleby M . Gestational age at birth and mortality in young adulthood. JAMA. 2011; 306(11):1233-40. DOI: 10.1001/jama.2011.1331. View

13.

Goldenberg R, Culhane J, Iams J, Romero R . Epidemiology and causes of preterm birth. Lancet. 2008; 371(9606):75-84. PMC: 7134569. DOI: 10.1016/S0140-6736(08)60074-4. View

14.

Orvos H, Hoffmann I, Frank I, Katona M, Pal A, Kovacs L . The perinatal outcome of pregnancy without prenatal care. A retrospective study in Szeged, Hungary. Eur J Obstet Gynecol Reprod Biol. 2001; 100(2):171-3. DOI: 10.1016/s0301-2115(01)00471-7. View

15.

Ronnenberg A, Wang X, Xing H, Chen C, Chen D, Guang W . Low preconception body mass index is associated with birth outcome in a prospective cohort of Chinese women. J Nutr. 2003; 133(11):3449-55. DOI: 10.1093/jn/133.11.3449. View

16.

Hofman P, Regan F, Jackson W, Jefferies C, Knight D, Robinson E . Premature birth and later insulin resistance. N Engl J Med. 2004; 351(21):2179-86. DOI: 10.1056/NEJMoa042275. View

17.

Blencowe H, Cousens S, Oestergaard M, Chou D, Moller A, Narwal R . National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications. Lancet. 2012; 379(9832):2162-72. DOI: 10.1016/S0140-6736(12)60820-4. View

18.

Zhang Y, Liu X, Gao S, Wang J, Gu Y, Zhang J . Risk factors for preterm birth in five Maternal and Child Health hospitals in Beijing. PLoS One. 2013; 7(12):e52780. PMC: 3531336. DOI: 10.1371/journal.pone.0052780. View

19.

Carmichael S, Abrams B . A critical review of the relationship between gestational weight gain and preterm delivery. Obstet Gynecol. 1997; 89(5 Pt 2):865-73. DOI: 10.1016/s0029-7844(97)00047-1. View

20.

Svedenkrans J, Henckel E, Kowalski J, Norman M, Bohlin K . Long-term impact of preterm birth on exercise capacity in healthy young men: a national population-based cohort study. PLoS One. 2013; 8(12):e80869. PMC: 3855651. DOI: 10.1371/journal.pone.0080869. View