Pathobiology of Ovarian Carcinomas

Overview

Journal Chin J Cancer

Publisher Biomed Central

Specialty Oncology

Date 2015 Jan 6

PMID 25556618

Citations 27

Authors

Mojgan Devouassoux-Shisheboran

Catherine Genestie

Affiliations

Soon will be listed here.

Abstract

Ovarian tumors comprise a heterogeneous group of lesions, displaying distinct tumor pathology and oncogenic potentiel. These tumors are subdivided into three main categories: epithelial, germ cell, and sex-cord stromal tumors. We report herein the newly described molecular abnormalities in epithelial ovarian cancers (carcinomas). Immunohistochemistry and molecular testing help pathologists to decipher the significant heterogeneity of this disease. Our better understanding of the molecular basis of ovarian carcinomas represents the first step in the development of targeted therapies in the near future.

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References

Mano M, Rosa D, Azambuja E, Ismael G, Braga S, DHondt V . Current management of ovarian carcinosarcoma. Int J Gynecol Cancer. 2007; 17(2):316-24. DOI: 10.1111/j.1525-1438.2006.00760.x. View

Lee Y, Miron A, Drapkin R, Nucci M, Medeiros F, Saleemuddin A . A candidate precursor to serous carcinoma that originates in the distal fallopian tube. J Pathol. 2006; 211(1):26-35. DOI: 10.1002/path.2091. View

Przybycin C, Kurman R, Ronnett B, Shih I, Vang R . Are all pelvic (nonuterine) serous carcinomas of tubal origin?. Am J Surg Pathol. 2010; 34(10):1407-16. DOI: 10.1097/PAS.0b013e3181ef7b16. View

Jones S, Wang T, Shih I, Mao T, Nakayama K, Roden R . Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma. Science. 2010; 330(6001):228-31. PMC: 3076894. DOI: 10.1126/science.1196333. View

Wiegand K, Shah S, Al-Agha O, Zhao Y, Tse K, Zeng T . ARID1A mutations in endometriosis-associated ovarian carcinomas. N Engl J Med. 2010; 363(16):1532-43. PMC: 2976679. DOI: 10.1056/NEJMoa1008433. View

DeLair D, Oliva E, Kobel M, Macias A, Gilks C, Soslow R . Morphologic spectrum of immunohistochemically characterized clear cell carcinoma of the ovary: a study of 155 cases. Am J Surg Pathol. 2010; 35(1):36-44. DOI: 10.1097/PAS.0b013e3181ff400e. View

Anglesio M, Carey M, Kobel M, MacKay H, Huntsman D . Clear cell carcinoma of the ovary: a report from the first Ovarian Clear Cell Symposium, June 24th, 2010. Gynecol Oncol. 2011; 121(2):407-15. DOI: 10.1016/j.ygyno.2011.01.005. View

. Integrated genomic analyses of ovarian carcinoma. Nature. 2011; 474(7353):609-15. PMC: 3163504. DOI: 10.1038/nature10166. View

Jones S, Wang T, Kurman R, Nakayama K, Velculescu V, Vogelstein B . Low-grade serous carcinomas of the ovary contain very few point mutations. J Pathol. 2011; 226(3):413-20. PMC: 3503448. DOI: 10.1002/path.3967. View

10.

Prat J . New insights into ovarian cancer pathology. Ann Oncol. 2012; 23 Suppl 10:x111-7. DOI: 10.1093/annonc/mds300. View

11.

Stewart C, McCluggage W . Epithelial-mesenchymal transition in carcinomas of the female genital tract. Histopathology. 2012; 62(1):31-43. DOI: 10.1111/his.12057. View

12.

Anglesio M, Kommoss S, Tolcher M, Clarke B, Galletta L, Porter H . Molecular characterization of mucinous ovarian tumours supports a stratified treatment approach with HER2 targeting in 19% of carcinomas. J Pathol. 2012; 229(1):111-20. DOI: 10.1002/path.4088. View

13.

Grisham R, Iyer G, Garg K, DeLair D, Hyman D, Zhou Q . BRAF mutation is associated with early stage disease and improved outcome in patients with low-grade serous ovarian cancer. Cancer. 2012; 119(3):548-554. PMC: 3961140. DOI: 10.1002/cncr.27782. View

14.

Romero I, Sun C, Wong K, Bast Jr R, Gershenson D . Low-grade serous carcinoma: new concepts and emerging therapies. Gynecol Oncol. 2013; 130(3):660-6. DOI: 10.1016/j.ygyno.2013.05.021. View

15.

Yamashita Y, Nagasaka T, Naiki-Ito A, Sato S, Suzuki S, Toyokuni S . Napsin A is a specific marker for ovarian clear cell adenocarcinoma. Mod Pathol. 2014; 28(1):111-7. DOI: 10.1038/modpathol.2014.61. View

16.

Lee K, Scully R . Mucinous tumors of the ovary: a clinicopathologic study of 196 borderline tumors (of intestinal type) and carcinomas, including an evaluation of 11 cases with 'pseudomyxoma peritonei'. Am J Surg Pathol. 2000; 24(11):1447-64. DOI: 10.1097/00000478-200011000-00001. View

17.

Rodriguez I, Prat J . Mucinous tumors of the ovary: a clinicopathologic analysis of 75 borderline tumors (of intestinal type) and carcinomas. Am J Surg Pathol. 2002; 26(2):139-52. DOI: 10.1097/00000478-200202000-00001. View

18.

Shappell H, Riopel M, Smith Sehdev A, Ronnett B, Kurman R . Diagnostic criteria and behavior of ovarian seromucinous (endocervical-type mucinous and mixed cell-type) tumors: atypical proliferative (borderline) tumors, intraepithelial, microinvasive, and invasive carcinomas. Am J Surg Pathol. 2002; 26(12):1529-41. DOI: 10.1097/00000478-200212000-00001. View

19.

Malpica A, Deavers M, Lu K, Bodurka D, Atkinson E, Gershenson D . Grading ovarian serous carcinoma using a two-tier system. Am J Surg Pathol. 2004; 28(4):496-504. DOI: 10.1097/00000478-200404000-00009. View

20.

Fathalla M . Incessant ovulation--a factor in ovarian neoplasia?. Lancet. 1971; 2(7716):163. DOI: 10.1016/s0140-6736(71)92335-x. View