Loss of MXD3 Induces Apoptosis of Reh Human Precursor B Acute Lymphoblastic Leukemia Cells

Overview

Journal Blood Cells Mol Dis

Specialty Hematology

Date 2015 Jan 3

PMID 25554682

Citations 14

Authors

Gustavo A Barisone

Noriko Satake

Carly Lewis

Connie Duong

Cathy Chen

Kit S Lam

Jan Nolta

Elva Diaz

Affiliations

Soon will be listed here.

Abstract

MXD3 is a transcription factor that plays an important role in proliferation of human DAOY medulloblastoma cells. Here, we demonstrate that MXD3 is highly enriched in human precursor B acute lymphoblastic leukemia (preB ALL) samples compared to mobilized peripheral blood mononuclear cells, bone marrow, or hematopoietic stem cells from healthy donors. MXD3 knock-down in the preB ALL cell line Reh resulted in decreased cell numbers with no change in G0/G1, S or G2/M populations but increased apoptosis compared to control cells. Our results suggest that MXD3 is important for survival of Reh preB ALL cells, possibly as an anti-apoptotic factor.

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