CEP2 Attenuates Myoblast Differentiation but Does Not Affect Proliferation

Overview

Journal Int J Biol Sci

Specialty Biology

Date 2015 Jan 2

PMID 25552934

Citations 8

Authors

Ming Wu

Gongshe Yang

Yaosheng Chen

Xingyu Zhou

Hu Chen

Mingsen Li

Kaifan Yu

Xumeng Zhang

Shuihua Xie

Ying Zhang

Guiyan Chu

Delin Mo

Affiliations

Soon will be listed here.

Abstract

CEP2 (CDC42EP2) is a member of the CDC42 subfamily that belongs to the Rho family. The Rho family plays an important role in a variety of cellular processes including skeletal myogenesis. Here, we find the expression of CEP2 increased significantly during C2C12 myogenesis. Overexpression of CEP2 could attenuate myoblast differentiation, while knockdown of CEP2 by siRNA results in enhancing myogenesis. Furthermore, we demonstrate for the first time that CEP2 attenuates myoblast differentiation via suppression of muscle regulatory factors (MRFs) rather than influencing myoblast proliferation. These results indicate that CEP2 acts as a repressor during myogenesis, which provides new insights into the role of CEP2 in muscle development.

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