Agenesis of the Corpus Callosum Associated with Spinal Open Neural Tube Defect

Overview

Journal Saudi Med J

Specialty General Medicine

Date 2015 Jan 1

PMID 25551114

Citations 1

Authors

Essam A Elgamal

Sherif M Elwatidy

Amro F Alhabib

Zain B Jamjoom

Waleed R Murshid

Hamdy H Hassan

Mustafa A Salih

Affiliations

Soon will be listed here.

Abstract

Objective: To ascertain the incidence and clinical implications of agenesis of the corpus callosum (ACC) in spinal open neural tube defects (SONTD).

Methods: All cases of SONTD registered at the Spina Bifida Clinic in King Khalid University Hospital, Riyadh, Saudi Arabia between 1995 and 2010 were retrospectively reviewed, and mid-sagittal MRI of the corpus callosum (CC) area was analyzed in each case. Neurodevelopmental outcome was classified as poor in children with seizures, severe neurodevelopmental impairment, or death.

Results: Thirty-eight patients (45.8%) with ACC were identified among 83 cases with SONTD. Patients' age ranged between one and 16 years. Total ACC was found in 10 patients, partial ACC in 25, and in 3 patients, the CC was hypoplastic. Active hydrocephalus was an associated finding in 9 out of 10 patients with total ACC, 22 out of 25 with partial ACC, and in all patients with hypoplasia of the CC. Thirteen patients (34.2%) had normal intellectual function, whereas 24 patients presented with learning disability, epilepsy, or poor intellectual function; and one patient died of respiratory failure.

Conclusion: Agenesis of the corpus callosum is found in a significant portion of patients with SONTD. When associated with hydrocephalus, its presence affects neuro-developmental outcome.

Citing Articles

Neural tube defects. Challenging, yet preventable.

Salih M Saudi Med J. 2015; 35 Suppl 1:S3-4.

PMID: 25551109 PMC: 4362093.

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