New Steroid Derivative with Hypoglycemic Activity

Overview

Journal Int J Clin Exp Med

Specialty General Medicine

Date 2015 Jan 1

PMID 25550906

Citations 3

Authors

Figueroa-Valverde Lauro

Diaz-Cedillo Francisco

Hau-Heredia Lenin

Garcia-Cervera Elodia

Pool-Gomez Eduardo

Rosas-Nexticapa Marcela

Sarabia-Alcocer Bety

Affiliations

Soon will be listed here.

Abstract

Data indicates that some steroid derivatives may induce changes on glucose levels; nevertheless, data are very confusing. Therefore, more pharmacological data are needed to characterize the activity induced by the steroid derivatives on glucose levels. The aim of this study was to synthesize a new steroid derivative for evaluate its hypoglycemic activity. The effects of steroid derivative on glucose concentration were evaluated in a diabetic animal model using glibenclamide and metformin as controls. In addition, the pregnenolone-dihydrotestosterone conjugate was bound to Tc-99m using radioimmunoassay methods, to evaluate the pharmacokinetics of the steroid derivative over time. The results showed that the pregnenolone-dihydrotestosterone conjugate induces changes on the glucose levels in similar form than glibenclamide. Other data showed that the biodistribution of Tc-99m-steroid derivativein brain was higher in comparison with spleen, stomach, intestine liver and kidney. In conclusion, the pregnenolone-dihydrotestosterone conjugate exerts hypoglycemic activity and this phenomenon could depend of its physicochemical properties which could be related to the degree of lipophilicity of the steroidderivative.

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