Relationship Between Red Cell Distribution Width and Long-term Mortality in Patients with Non-ST Elevation Acute Coronary Syndrome

Overview

Journal Anatol J Cardiol

Publisher Kare Publishing

Specialty Cardiology & Vascular Diseases

Date 2015 Jan 1

PMID 25550178

Citations 13

Authors

Adem Bekler

Erhan Tenekecioglu

Gokhan Erbag

Ahmet Temiz

Burak Altun

Ahmet Barutcu

Emine Gazi

Fahri Gunes

Mustafa Yilmaz

Affiliations

Soon will be listed here.

Abstract

Objective: Red cell distribution width (RDW) has been reported to be a predictor of cardiac events in coronary artery disease (CAD). Here, we hypothesized that RDW level on admission would be predictive of adverse outcomes in non-ST elevation acute coronary syndrome (NST-ACS).

Methods: In total, 202 patients with NST-ACS (159 males and 43 females) were retrospectively analyzed. The patients were divided into two groups based on the 50th percentile of admission RDW levels. A high RDW group (n=100) was defined as those patients having RDW levels of >14.0. The relationship between RDW and primary endpoint (cardiovascular death), secondary endpoints [(reinfarction, repeat target vessel revascularization-percutaneous/surgical)], and major adverse cardiac events (MACE) were assessed. The median follow-up time was 18 (13-24) months.

Results: The patients in the high RDW group were older (62.9 vs. 57.5, p = 0.001). Multivessel disease, low-density lipoprotein, creatinine, platelet, CK-MB, troponin I, and RDW were higher (p = 0.047, p = 0.003, p = 0.012, p = 0.012, p = 0.017, p < 0.001, respectively), and gender (male/female), ejection fraction, and hemoglobin levels were lower (p = 0.021, p = 0.04, p = 0.016, respectively) in the high RDW group. Cardiovascular death and MACE were higher in the high RDW group (16% vs. 4.9%, p = 0.01, 52% vs. 31.4%, p = 0.003, respectively). By multiple regression analysis in 202 patients, age ≥ 65 and RDW >14.0% on admission were found to be powerful independent predictors of cardiovascular mortality (OR: 4.5, 95% CI: 1.5-13.1, p = 0.005, OR: 3.0, 95% CI: 1.0-8.9, p = 0.039, respectively).

Conclusion: A high RDW level on admission is associated with increased long-term mortality in patients with NST-ACS.

Citing Articles

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Correlation of the changing trends of red cell distribution width and serum lactate as a prognostic factor in sepsis and septic shock.

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Prognostic Impact of Red Cell Distribution Width on the Development of Contrast-Induced Nephropathy, Major Adverse Cardiac Events, and Mortality in Coronary Artery Disease Patients Undergoing Percutaneous Coronary Intervention.

Latif A, Ahsan M, Lateef N, Kapoor V, Fazeel H, Razzaq F Curr Cardiol Rev. 2021; 17(6):e051121191160.

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Red Cell Distribution Width and Mortality in Patients With Acute Coronary Syndrome: A Meta-Analysis on Prognosis.

Abrahan 4th L, Ramos J, Cunanan E, Tiongson M, Punzalan F Cardiol Res. 2018; 9(3):144-152.

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Combined value of red blood cell distribution width and global registry of acute coronary events risk score on predicting long-term major adverse cardiac events in STEMI patients undergoing primary PCI.

Chang X, Zhang S, Wang H, Zhang M, Zheng W, Ma H Oncotarget. 2018; 9(17):13971-13980.

PMID: 29568409 PMC: 5862630. DOI: 10.18632/oncotarget.24128.

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