TRNAs As Antibiotic Targets

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2014 Dec 31

PMID 25547494

Citations 17

Authors

Shaileja Chopra

John Reader

Affiliations

Soon will be listed here.

Abstract

Transfer RNAs (tRNAs) are central players in the protein translation machinery and as such are prominent targets for a large number of natural and synthetic antibiotics. This review focuses on the role of tRNAs in bacterial antibiosis. We will discuss examples of antibiotics that target multiple stages in tRNA biology from tRNA biogenesis and modification, mature tRNAs, aminoacylation of tRNA as well as prevention of proper tRNA function by small molecules binding to the ribosome. Finally, the role of deacylated tRNAs in the bacterial "stringent response" mechanism that can lead to bacteria displaying antibiotic persistence phenotypes will be discussed.

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