Diagnosis of Invasive Fungal Diseases in Hematological Malignancies: A Critical Review of Evidence and Turkish Expert Opinion (TEO-2)

Overview

Journal Turk J Haematol

Specialty Hematology

Date 2014 Dec 27

PMID 25541650

Authors

Sevtap Arikan Akdagli

Alpay Azap

Figen Basaran Demirkazik

Beyza Ener

Sibel Ascioglu Hayran

Ozlem Ozdemir Kumbasar

Gokhan Metan

Zekaver Odabasi

Omrum Uzun

Hamdi Akan

Affiliations

Soon will be listed here.

Abstract

One of the most problematic issues in hematological malignancies is the diagnosis of invasive fungal diseases. Especially, the difficulty of mycological diagnosis and the necessity of immediate intervention in molds have led to the adoption of "surrogate markers" that do not verify but rather strongly suggest fungal infection. The markers commonly used are galactomannan (GM), beta-glucan, and imaging methods. Although there are numerous studies on these diagnostic approaches, none of these markers serve as a support for the clinician, as is the case in human immunodeficiency virus (HIV) or cytomegalovirus (CMV) infections. This paper has been prepared to explain the diagnostic tests. As molecular tests have not been standardized and are not used routinely in the clinics, they will not be mentioned here.

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