Occult Prostate Cancer Detected with 18F-Fluorocholine Positron Emission Tomography/Computed Tomography

Overview

Journal World J Nucl Med

Publisher Thieme

Specialty Nuclear Medicine

Date 2014 Dec 25

PMID 25538495

Citations 1

Authors

Wanying Xie

Andrew Eik Hock Tan

Christopher Cheng

Anthony Goh Soon Whatt

Affiliations

Soon will be listed here.

Abstract

We present a case of a 63-year-old gentleman, who had an initial negative prostate needle biopsy, but persistently elevated prostate-specific antigen levels. An magnetic resonance imaging study of the prostate failed to demonstrate the presence of malignancy. 18F-fluorocholine positron emission tomography/computed tomography (PET/CT) was then acquired which revealed suspicious prostate lesions. These were confirmed by subsequent surgery and histology to represent prostatic carcinoma.

Citing Articles

Radiation treatment monitoring using multimodal functional imaging: PET/CT ((18)F-Fluoromisonidazole & (18)F-Fluorocholine) and DCE-US.

Arteaga-Marrero N, Rygh C, Mainou-Gomez J, Adamsen T, Lutay N, Reed R J Transl Med. 2015; 13:383.

PMID: 26682742 PMC: 4683758. DOI: 10.1186/s12967-015-0708-5.

References

Hofer C, Laubenbacher C, Block T, Breul J, Hartung R, Schwaiger M . Fluorine-18-fluorodeoxyglucose positron emission tomography is useless for the detection of local recurrence after radical prostatectomy. Eur Urol. 1999; 36(1):31-5. DOI: 10.1159/000019923. View

Igerc I, Kohlfurst S, Gallowitsch H, Matschnig S, Kresnik E, Gomez-Segovia I . The value of 18F-choline PET/CT in patients with elevated PSA-level and negative prostate needle biopsy for localisation of prostate cancer. Eur J Nucl Med Mol Imaging. 2008; 35(5):976-83. DOI: 10.1007/s00259-007-0686-9. View

Nakagami K, Uchida T, Ohwada S, Koibuchi Y, Suda Y, Sekine T . Increased choline kinase activity and elevated phosphocholine levels in human colon cancer. Jpn J Cancer Res. 1999; 90(4):419-24. PMC: 5926083. DOI: 10.1111/j.1349-7006.1999.tb00764.x. View

Kwee S, Thibault G, Stack R, Coel M, Furusato B, Sesterhenn I . Use of step-section histopathology to evaluate 18F-fluorocholine PET sextant localization of prostate cancer. Mol Imaging. 2008; 7(1):12-20. View

Wefer A, Hricak H, Vigneron D, Coakley F, Lu Y, Wefer J . Sextant localization of prostate cancer: comparison of sextant biopsy, magnetic resonance imaging and magnetic resonance spectroscopic imaging with step section histology. J Urol. 2000; 164(2):400-4. View

DeGrado T, Baldwin S, Wang S, Orr M, Liao R, Friedman H . Synthesis and evaluation of (18)F-labeled choline analogs as oncologic PET tracers. J Nucl Med. 2001; 42(12):1805-14. View

Liu I, Zafar M, Lai Y, Segall G, Terris M . Fluorodeoxyglucose positron emission tomography studies in diagnosis and staging of clinically organ-confined prostate cancer. Urology. 2001; 57(1):108-11. DOI: 10.1016/s0090-4295(00)00896-7. View

Effert P, Bares R, Handt S, Wolff J, Bull U, Jakse G . Metabolic imaging of untreated prostate cancer by positron emission tomography with 18fluorine-labeled deoxyglucose. J Urol. 1996; 155(3):994-8. View

Mazaheri Y, Shukla-Dave A, Muellner A, Hricak H . MR imaging of the prostate in clinical practice. MAGMA. 2008; 21(6):379-92. DOI: 10.1007/s10334-008-0138-y. View

10.

Price D, Coleman R, Liao R, Robertson C, Polascik T, DeGrado T . Comparison of [18 F]fluorocholine and [18 F]fluorodeoxyglucose for positron emission tomography of androgen dependent and androgen independent prostate cancer. J Urol. 2002; 168(1):273-80. View

11.

Negendank W . Studies of human tumors by MRS: a review. NMR Biomed. 1992; 5(5):303-24. DOI: 10.1002/nbm.1940050518. View

12.

Yamaguchi T, Lee J, Uemura H, Sasaki T, Takahashi N, Oka T . Prostate cancer: a comparative study of 11C-choline PET and MR imaging combined with proton MR spectroscopy. Eur J Nucl Med Mol Imaging. 2005; 32(7):742-8. DOI: 10.1007/s00259-004-1755-y. View

13.

Kwee S, Wei H, Sesterhenn I, Yun D, Coel M . Localization of primary prostate cancer with dual-phase 18F-fluorocholine PET. J Nucl Med. 2006; 47(2):262-9. View

14.

Cornel E, Smits G, Oosterhof G, Karthaus H, Deburyne F, Schalken J . Characterization of human prostate cancer, benign prostatic hyperplasia and normal prostate by in vitro 1H and 31P magnetic resonance spectroscopy. J Urol. 1993; 150(6):2019-24. DOI: 10.1016/s0022-5347(17)35957-8. View

15.

Rabbani F, Stroumbakis N, Kava B, Cookson M, Fair W . Incidence and clinical significance of false-negative sextant prostate biopsies. J Urol. 1998; 159(4):1247-50. View