Repurposing Drugs in Oncology (ReDO)-cimetidine As an Anti-cancer Agent

Overview

Journal Ecancermedicalscience

Specialty Oncology

Date 2014 Dec 20

PMID 25525463

Citations 22

Authors

Pan Pantziarka

Gauthier Bouche

Lydie Meheus

Vidula Sukhatme

Vikas P Sukhatme

Affiliations

Soon will be listed here.

Abstract

Cimetidine, the first H2 receptor antagonist in widespread clinical use, has anti-cancer properties that have been elucidated in a broad range of pre-clinical and clinical studies for a number of different cancer types. These data are summarised and discussed in relation to a number of distinct mechanisms of action. Based on the evidence presented, it is proposed that cimetidine would synergise with a range of other drugs, including existing chemotherapeutics, and that further exploration of the potential of cimetidine as an anti-cancer therapeutic is warranted. Furthermore, there is compelling evidence that cimetidine administration during the peri-operative period may provide a survival benefit in some cancers. A number of possible combinations with other drugs are discussed in the supplementary material accompanying this paper.

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