Chlorpyrifos Exposure and Respiratory Health Among Adolescent Agricultural Workers

Overview

Journal Int J Environ Res Public Health

Publisher MDPI

Specialties Environmental Health
Public Health

Date 2014 Dec 19

PMID 25522051

Citations 12

Authors

Catherine L Callahan

Manal Al-Batanony

Ahmed A Ismail

Gaafar Abdel-Rasoul

Olfat Hendy

James R Olson

Diane S Rohlman

Matthew R Bonner

Affiliations

Soon will be listed here.

Abstract

Chlorpyrifos (CPF) is a commonly used organophosphate insecticide (OP). In adults, exposure to OPs has been inconsistently associated with reduced lung function. OP exposure and lung function has not been assessed in adolescents. The objective of this study was to assess CPF exposure and lung function among Egyptian adolescents. We conducted a 10-month study of male adolescent pesticide applicators (n = 38) and non-applicators of similar age (n = 24). Urinary 3,5,6-trichloro-2-pyridinol (TPCy), a CPF-specific metabolite, was analyzed in specimens collected throughout the study. Spirometry was performed twice after pesticide application: day 146, when TCPy levels were elevated and day 269, when TCPy levels were near baseline. Applicators had higher levels of TCPy (mean cumulative TCPy day 146 = 33,217.6; standard deviation (SD) = 49,179.3) than non-applicators (mean cumulative TCPy day 146 = 3290.8; SD = 3994.9). Compared with non-applicators, applicators had higher odds of reporting wheeze, odds ratio = 3.41 (95% CI: 0.70; 17.41). Cumulative urinary TCPy was inversely associated with spirometric measurements at day 146, but not at day 269. Although generally non-significant, results were consistent with an inverse association between exposure to CPF and lung function.

Citing Articles

Impact of chlorpyrifos exposure on lung function in Egyptian adolescent agriculture workers.

Mendez E, Davis J, Bonner M, Abdel Rasoul G, Ismail A, Hendy O Arch Environ Occup Health. 2024; 79(3-4):121-129.

PMID: 38993119 PMC: 11392629. DOI: 10.1080/19338244.2024.2374582.

The Health Impacts of Hazardous Chemical Exposures among Child Labourers in Low- and Middle-Income Countries.

Scott N, Pocock N Int J Environ Res Public Health. 2021; 18(10).

PMID: 34065553 PMC: 8160821. DOI: 10.3390/ijerph18105496.

Organophosphate and carbamate insecticide exposure is related to lung function change among smallholder farmers: a prospective study.

Hansen M, Jors E, Sandbaek A, Sekabojja D, Ssempebwa J, Mubeezi R Thorax. 2021; .

PMID: 33479045 PMC: 8311090. DOI: 10.1136/thoraxjnl-2020-214609.

Gestational Pesticide Exposure and Child Respiratory Health.

Gilden R, Friedmann E, Holmes K, Yolton K, Xu Y, Lanphear B Int J Environ Res Public Health. 2020; 17(19).

PMID: 33007939 PMC: 7579149. DOI: 10.3390/ijerph17197165.

Risk perception and behavior in Egyptian adolescent pesticide applicators: an intervention study.

Rohlman D, Davis J, Ismail A, Abdel Rasoul G, Hendy O, Olson J BMC Public Health. 2020; 20(1):679.

PMID: 32404149 PMC: 7222587. DOI: 10.1186/s12889-020-08801-7.

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