High-protein Diet Improves Postoperative Weight Gain After Massive Small-bowel Resection

Overview

Journal J Gastrointest Surg

Specialty Gastroenterology

Date 2014 Dec 19

PMID 25519080

Citations 1

Authors

Raphael C Sun

Pamela M Choi

Jose Diaz-Miron

Joshua Sommovilla

Jun Guo

Christopher R Erwin

Brad W Warner

Affiliations

Soon will be listed here.

Abstract

Introduction: Short bowel syndrome (SBS) is a morbid clinical condition that results from massive small-bowel resection (SBR). After SBR, there is a dramatic weight loss in the acute postoperative period. Our aim was to determine the impact of a high-protein diet (HPD) on weight gain and body composition in mice after SBR.

Methods: C57BL/6 mice underwent 50 % proximal SBR. Postoperatively, mice were randomly selected to receive standard rodent liquid diet (LD) (n = 6) or an isocaloric HPD (n = 9) for 28 days. Mice weights were recorded daily. Body composition analyses were obtained weekly. Student's t test was used for statistical comparisons with p < 0.05 considered significant.

Results: Mice that were fed HPD after SBR returned to baseline weight on average at postoperative day (POD) 8 versus mice that were fed LD that returned to baseline weight on average at POD 22. Total fat mass and lean mass were significantly greater by POD 14 within the HPD group. Both groups of mice demonstrated normal structural adaptation.

Conclusion: HPD results in greater weight gain and improved body composition in mice after SBR. This finding may be clinically important for patients with SBS since improved weight gain may reduce the time needed for parenteral nutrition.

Citing Articles

Intestinal Epithelial-Specific mTORC1 Activation Enhances Intestinal Adaptation After Small Bowel Resection.

Barron L, Sun R, Aladegbami B, Erwin C, Warner B, Guo J Cell Mol Gastroenterol Hepatol. 2017; 3(2):231-244.

PMID: 28275690 PMC: 5331783. DOI: 10.1016/j.jcmgh.2016.10.006.

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