Salvage Cryosurgery for Locally Recurrent Prostate Cancer After Primary Cryotherapy

Overview

Journal Int Urol Nephrol

Publisher Springer

Specialty Nephrology

Date 2014 Dec 17

PMID 25510358

Citations 6

Authors

Xiaofeng Chang

Tieshi Liu

Fan Zhang

Xiaozhi Zhao

Changwei Ji

Rong Yang

Weidong Gan

Gutian Zhang

Xiaogong Li

Hongqian Guo

Affiliations

Soon will be listed here.

Abstract

Objective: To report our preliminary experience of salvage cryosurgery (SCS) for locally recurrent prostate cancer (PCa) after primary cryotherapy and determine the efficacy of cryoablation of the prostate in the salvage setting.

Patients And Methods: We conducted a retrospective review of the records of all patients who underwent SCS for locally recurrent PCa after primary cryotherapy between February 2008 and March 2012. Patients were assessed after treatment by prostate-specific antigen (PSA) testing, transrectal ultrasonography, radiologic imaging, and biopsy. Biochemical failure was defined using the Phoenix criteria.

Results: Data from 12 patients who had undergone SCS were entered. Median age at SCS was 77.5 year. Before SCS, patients had a median PSA level of 2.5 ng/ml and median Gleason sum of 7. Patients underwent SCS at a median of 7.8 months after primary CS. Median PSA nadir after SCS was 1.32 ng/ml. The mean (range) follow-up was 33.5 months. Three patients were started on hormonal therapy for disease progression at a median post-SCS period of 12 months. Two patients underwent repeat cryoablation. Only one patient developed mild incontinence after SCS. Urethral sloughing occurred in one patient. Only two patients suffered from transient impotence.

Conclusions: It is feasible for patients with PCa to adopt SCS when primary cryotherapy has failed. The application of SCS also allows hormonal therapy to be deferred for a sufficient period of time.

Citing Articles

The Role of Whole-Gland and Focal Cryotherapy in Recurrent Prostate Cancer.

Pio F, Murdock A, Fuller R, Whalen M Cancers (Basel). 2024; 16(18).

PMID: 39335196 PMC: 11430134. DOI: 10.3390/cancers16183225.

Salvage treatments after focal therapy for prostate cancer - a comprehensive review.

Ramacciotti L, Abreu A, Crouzet S, Macek P, Miles B, Horuz R Prostate Cancer Prostatic Dis. 2024; .

PMID: 39090369 DOI: 10.1038/s41391-024-00875-3.

Analysis of Several Pathways for Efficient Killing of Prostate Cancer Stem Cells: A Central Role of NF-κB RELA.

Witte K, Pfitzenmaier J, Storm J, Lutkemeyer M, Wimmer C, Schulten W Int J Mol Sci. 2021; 22(16).

PMID: 34445612 PMC: 8396252. DOI: 10.3390/ijms22168901.

Complications, oncological and functional outcomes of salvage treatment options following focal therapy for localized prostate cancer: a systematic review and a comprehensive narrative review.

Marra G, Gontero P, Walz J, Sivaraman A, Tourinho-Barbosa R, Cathelineau X World J Urol. 2019; 37(8):1517-1534.

PMID: 30710157 DOI: 10.1007/s00345-019-02642-9.

Cryosurgery would be An Effective Option for Clinically Localized Prostate Cancer: A Meta-analysis and Systematic Review.

Gao L, Yang L, Qian S, Tang Z, Qin F, Wei Q Sci Rep. 2016; 6:27490.

PMID: 27271239 PMC: 4895342. DOI: 10.1038/srep27490.

References

Pisters L, Von Eschenbach A, Scott S, Swanson D, Dinney C, Pettaway C . The efficacy and complications of salvage cryotherapy of the prostate. J Urol. 1997; 157(3):921-5. View

Bahn D, Lee F, Silverman P, Bahn E, Badalament R, Kumar A . Salvage cryosurgery for recurrent prostate cancer after radiation therapy: a seven-year follow-up. Clin Prostate Cancer. 2004; 2(2):111-4. DOI: 10.3816/cgc.2003.n.018. View

Ward J, Stephen Jones J . Focal cryotherapy for localized prostate cancer: a report from the national Cryo On-Line Database (COLD) Registry. BJU Int. 2011; 109(11):1648-54. DOI: 10.1111/j.1464-410X.2011.10578.x. View

Bahn D, De Castro Abreu A, Gill I, Hung A, Silverman P, Gross M . Focal cryotherapy for clinically unilateral, low-intermediate risk prostate cancer in 73 men with a median follow-up of 3.7 years. Eur Urol. 2012; 62(1):55-63. DOI: 10.1016/j.eururo.2012.03.006. View

Jemal A, Thomas A, Murray T, Thun M . Cancer statistics, 2002. CA Cancer J Clin. 2002; 52(1):23-47. DOI: 10.3322/canjclin.52.1.23. View

. Consensus statement: guidelines for PSA following radiation therapy. American Society for Therapeutic Radiology and Oncology Consensus Panel. Int J Radiat Oncol Biol Phys. 1997; 37(5):1035-41. View

Chin J, Touma N, Pautler S, Guram K, Bella A, Downey D . Serial histopathology results of salvage cryoablation for prostate cancer after radiation failure. J Urol. 2003; 170(4 Pt 1):1199-202. DOI: 10.1097/01.ju.0000085620.28141.40. View

Eisenberg M, Shinohara K . Partial salvage cryoablation of the prostate for recurrent prostate cancer after radiotherapy failure. Urology. 2008; 72(6):1315-8. DOI: 10.1016/j.urology.2008.03.040. View

Dhar N, Ward J, Cher M, Stephen Jones J . Primary full-gland prostate cryoablation in older men (> age of 75 years): results from 860 patients tracked with the COLD Registry. BJU Int. 2011; 108(4):508-12. DOI: 10.1111/j.1464-410X.2011.10238.x. View

10.

Lian H, Guo H, Gan W, Li X, Yan X, Wang W . Cryosurgery as primary treatment for localized prostate cancer. Int Urol Nephrol. 2011; 43(4):1089-94. DOI: 10.1007/s11255-011-9952-7. View

11.

Philippou P, Yap T, Chinegwundoh F . Third-generation salvage cryotherapy for radiorecurrent prostate cancer: a centre's experience. Urol Int. 2012; 88(2):137-44. DOI: 10.1159/000332220. View

12.

Stephen Jones J, Rewcastle J, Donnelly B, Lugnani F, Pisters L, Katz A . Whole gland primary prostate cryoablation: initial results from the cryo on-line data registry. J Urol. 2008; 180(2):554-8. DOI: 10.1016/j.juro.2008.04.027. View

13.

Pisters L, Rewcastle J, Donnelly B, Lugnani F, Katz A, Stephen Jones J . Salvage prostate cryoablation: initial results from the cryo on-line data registry. J Urol. 2008; 180(2):559-63. DOI: 10.1016/j.juro.2008.04.005. View

14.

Ng C, Moussa M, Downey D, Chin J . Salvage cryoablation of the prostate: followup and analysis of predictive factors for outcome. J Urol. 2007; 178(4 Pt 1):1253-7. DOI: 10.1016/j.juro.2007.05.137. View

15.

Grimm P, Billiet I, Bostwick D, Dicker A, Frank S, Immerzeel J . Comparative analysis of prostate-specific antigen free survival outcomes for patients with low, intermediate and high risk prostate cancer treatment by radical therapy. Results from the Prostate Cancer Results Study Group. BJU Int. 2012; 109 Suppl 1:22-9. DOI: 10.1111/j.1464-410X.2011.10827.x. View

16.

Ghafar M, Johnson C, de la Taille A, Benson M, Bagiella E, Fatal M . Salvage cryotherapy using an argon based system for locally recurrent prostate cancer after radiation therapy: the Columbia experience. J Urol. 2001; 166(4):1333-7; discussion 1337-8. View

17.

Cohen J, Miller Jr R, Ahmed S, Lotz M, Baust J . Ten-year biochemical disease control for patients with prostate cancer treated with cryosurgery as primary therapy. Urology. 2008; 71(3):515-8. DOI: 10.1016/j.urology.2007.09.059. View

18.

Wenske S, Quarrier S, Katz A . Salvage cryosurgery of the prostate for failure after primary radiotherapy or cryosurgery: long-term clinical, functional, and oncologic outcomes in a large cohort at a tertiary referral centre. Eur Urol. 2012; 64(1):1-7. DOI: 10.1016/j.eururo.2012.07.008. View