Twist-BRD4 Complex: Potential Drug Target for Basal-like Breast Cancer

Overview

Journal Curr Pharm Des

Publisher Bentham Science Publishers

Date 2014 Dec 16

PMID 25506891

Citations 16

Authors

Jian Shi

Jingying Cao

Binhua P Zhou

Affiliations

Soon will be listed here.

Abstract

As an important basic helix-loop-helix (bHLH) transcription factor, Twist associates with several physiological processes such as mesodermal development, and pathological processes such as Saethre-Chotzen syndrome. During cancer progression, Twist induces epithelial-mesenchymal transition (EMT), potentiating cancer cell invasion and metastasis. Although many studies have revealed its multiple biological roles, it remained unclear how Twist transcriptionally activates targeted genes. Recently we discovered tip60-mediated Twist di-acetylation in the ''histone H4-mimic'' GK-X-GK motif. The di-acetylated Twist recruits BRD4 and related transcriptional components to super-enhancer of its targeted genes during progression of basal-like breast cancer (BLBC). Here, we review this new advance of regulation and functional mechanism of Twist.

Citing Articles

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