Neuroprotective Mechanism of BNG-1 Against Focal Cerebral Ischemia: a Neuroimaging and Neurotrophin Study

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2014 Dec 16

PMID 25506838

Citations 3

Authors

Nai-Fang Chi

Ho-Ling Liu

Jen-Tsung Yang

Jr-Rung Lin

Shu-Li Liao

Bo-Han Peng

Yen-Tung Lee

Tsong-Hai Lee

Affiliations

Soon will be listed here.

Abstract

BNG-1 is a herb complex used in traditional Chinese medicine to treat stroke. In this study, we attempted to identify the neuroprotective mechanism of BNG-1 by using neuroimaging and neurotrophin analyses of a stroke animal model. Rats were treated with either saline or BNG-1 for 7 d after 60-min middle cerebral artery occlusion by filament model. The temporal change of magnetic resonance (MR) imaging of brain was studied using a 7 Tesla MR imaging (MRI) system and the temporal expressions of neurotrophin-3 (NT-3), brain-derived neurotrophic factor (BDNF), and nerve growth factor (NGF) in brain were analyzed before operation and at 4 h, 2 d, and 7 d after operation. Compared with the saline group, the BNG-1 group exhibited a smaller infarction volume in the cerebral cortex in T2 image from as early as 4 h to 7 d, less edema in the cortex in diffusion weighted image from 2 to 7 d, earlier reduction of postischemic hyperperfusion in both the cortex and striatum in perfusion image at 4 h, and earlier normalization of the ischemic pattern in the striatum in susceptibility weighted image at 2 d. NT-3 and BDNF levels were higher in the BNG-1 group than the saline group at 7 d. We concluded that the protective effect of BNG-1 against cerebral ischemic injury might act through improving cerebral hemodynamics and recovering neurotrophin generation.

Citing Articles

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Improved thrombolytic effect with focused ultrasound and neuroprotective agent against acute carotid artery thrombosis in rat.

Lee T, Yeh J, Tsai C, Yang J, Lou S, Seak C Sci Rep. 2017; 7(1):1638.

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The Protective Effect of Human Umbilical Cord Blood CD34+ Cells and Estradiol against Focal Cerebral Ischemia in Female Ovariectomized Rat: Cerebral MR Imaging and Immunohistochemical Study.

Liang C, Liu H, Chang S, Chen S, Lee T PLoS One. 2016; 11(1):e0147133.

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