ViVar: a Comprehensive Platform for the Analysis and Visualization of Structural Genomic Variation

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2014 Dec 16

PMID 25503062

Citations 28

Authors

Tom Sante

Sarah Vergult

Pieter-Jan Volders

Wigard P Kloosterman

Geert Trooskens

Katleen De Preter

Annelies Dheedene

Frank Speleman

Tim De Meyer

Bjorn Menten

Affiliations

Soon will be listed here.

Abstract

Structural genomic variations play an important role in human disease and phenotypic diversity. With the rise of high-throughput sequencing tools, mate-pair/paired-end/single-read sequencing has become an important technique for the detection and exploration of structural variation. Several analysis tools exist to handle different parts and aspects of such sequencing based structural variation analyses pipelines. A comprehensive analysis platform to handle all steps, from processing the sequencing data, to the discovery and visualization of structural variants, is missing. The ViVar platform is built to handle the discovery of structural variants, from Depth Of Coverage analysis, aberrant read pair clustering to split read analysis. ViVar provides you with powerful visualization options, enables easy reporting of results and better usability and data management. The platform facilitates the processing, analysis and visualization, of structural variation based on massive parallel sequencing data, enabling the rapid identification of disease loci or genes. ViVar allows you to scale your analysis with your work load over multiple (cloud) servers, has user access control to keep your data safe and is easy expandable as analysis techniques advance. URL: https://www.cmgg.be/vivar/

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