A Review on Pharmacological and Analytical Aspects of Naringenin

Overview

Journal Chin J Integr Med

Date 2014 Dec 16

PMID 25501296

Citations 68

Authors

Kanika Patel

Gireesh Kumar Singh

Dinesh Kumar Patel

Affiliations

Soon will be listed here.

Abstract

Flavonoids are a widely distributed group of phytochemicals having benzo-pyrone nucleus, and more than 4,000 different flavonoids have been described and categorized into flavonols, flavones, flavanones, isoflavones, catechins and anthocyanidins. Flavonoids occurs naturally in fruits, vegetables, nuts, and beverages such as coffee, tea, and red wine, as well as in medical herbs. Flavonoids are responsible for the different colors of plant parts and are important constituents of the human diet. Flavanoids have different pharmacological activities, such as antioxidant, anti-allergic, antibacterial, anti-inflammatory, antimutagenic and anticancer activity. Naringenin belongs to the flavanones and is mainly found in fruits (grapefruit and oranges) and vegetables. Pharmacologically, it has anticancer, antimutagenic, anti-inflammatory, antioxidant, antiproliferative and antiatherogenic activities. Naringenin is used for the treatments of osteoporosis, cancer and cardiovascular diseases, and showed lipid-lowering and insulin-like properties. In the present review, detailed pharmacological and analytical aspects of naringenin have been presented, which revealed the impressive pharmacological profile and the possible usefulness in the treatment of different types of diseases in the future. The information provided in this communication will act as an important source for development of effective medicines for the treatment of various disorders.

Citing Articles

Efficacy of Naringenin against aging and degeneration of nucleus pulposus cells through IGFBP3 inhibition.

Tang X, Zhong J, Luo H, Zhou F, Wang L, Lin S Sci Rep. 2025; 15(1):6780.

PMID: 40000729 PMC: 11861589. DOI: 10.1038/s41598-025-90909-0.

Mechanism of PRRSV infection and antiviral role of polyphenols.

Amona F, Pang Y, Gong X, Wang Y, Fang X, Zhang C Virulence. 2024; 15(1):2417707.

PMID: 39432383 PMC: 11497994. DOI: 10.1080/21505594.2024.2417707.

Flavonoids as modulators of metabolic reprogramming in renal cell carcinoma (Review).

Shahzad A, Liu W, Sun Y, Liu X, Xia J, Cui K Oncol Rep. 2024; 52(6).

PMID: 39422066 PMC: 11526433. DOI: 10.3892/or.2024.8826.

Biflavonoid Methylchamaejasmin and Khaya grandifoliola Extract Inhibit NLRP3 Inflammasome in THP-1 Cell Model of Neuroinflammation.

Owona B, Mary A, Messi A, Ravichandran K, Mbing J, Pegnyemb E Mol Neurobiol. 2024; 62(2):1605-1619.

PMID: 39012444 DOI: 10.1007/s12035-024-04365-4.

Phenolic Contents, Antioxidant Activities, LCMS Profiles of Mespilus germanica Leaf Extract and Effects on mRNA Transcription Levels of Apoptotic, Autophagic, and Necrotic Genes in MCF7 and A549 Cancer Cell Lines.

Gormez G, Yuksek V, Usta A, Dede S, Gumus S Cell Biochem Biophys. 2024; 82(3):2141-2155.

PMID: 38850406 DOI: 10.1007/s12013-024-01321-w.

References

Patel D, Laloo D, Kumar R, Hemalatha S . Pedalium murex Linn.: an overview of its phytopharmacological aspects. Asian Pac J Trop Med. 2011; 4(9):748-55. DOI: 10.1016/S1995-7645(11)60186-7. View

Iutynska H, Tytova L, Leonova N, Brovko I . [Activity of main enzymes of ammonium assimilation in Bradyrhizobium japonicum under the influence of plant flavonoid inductors]. Mikrobiol Z. 2011; 72(6):23-9. View

Funari C, Passalacqua T, Rinaldo D, Napolitano A, Festa M, Capasso A . Interconverting flavanone glucosides and other phenolic compounds in Lippia salviaefolia Cham. ethanol extracts. Phytochemistry. 2011; 72(16):2052-61. DOI: 10.1016/j.phytochem.2011.07.004. View

Tundis R, Loizzo M, Menichini F, Bonesi M, Colica C, Menichini F . In vitro cytotoxic activity of extracts and isolated constituents of Salvia leriifolia Benth. against a panel of human cancer cell lines. Chem Biodivers. 2011; 8(6):1152-62. DOI: 10.1002/cbdv.201000311. View

Mulvihill E, Allister E, Sutherland B, Telford D, Sawyez C, Edwards J . Naringenin prevents dyslipidemia, apolipoprotein B overproduction, and hyperinsulinemia in LDL receptor-null mice with diet-induced insulin resistance. Diabetes. 2009; 58(10):2198-210. PMC: 2750228. DOI: 10.2337/db09-0634. View

Duarte N, Lage H, Abrantes M, Ferreira M . Phenolic compounds as selective antineoplasic agents against multidrug-resistant human cancer cells. Planta Med. 2010; 76(10):975-80. DOI: 10.1055/s-0029-1240892. View

Boros B, Jakabova S, Dornyei A, Horvath G, Pluhar Z, Kilar F . Determination of polyphenolic compounds by liquid chromatography-mass spectrometry in Thymus species. J Chromatogr A. 2010; 1217(51):7972-80. DOI: 10.1016/j.chroma.2010.07.042. View

Moon Y, Wang X, Morris M . Dietary flavonoids: effects on xenobiotic and carcinogen metabolism. Toxicol In Vitro. 2005; 20(2):187-210. DOI: 10.1016/j.tiv.2005.06.048. View

Jain A, Yadav A, Bozhkov A, Padalko V, Flora S . Therapeutic efficacy of silymarin and naringenin in reducing arsenic-induced hepatic damage in young rats. Ecotoxicol Environ Saf. 2010; 74(4):607-14. DOI: 10.1016/j.ecoenv.2010.08.002. View

10.

Andreu-Navarro A, Fernandez-Romero J, Gomez-Hens A . Luminescent determination of flavonoids in orange juices by LC with post-column derivatization with aluminum and terbium. J Sep Sci. 2010; 33(4-5):509-15. DOI: 10.1002/jssc.200900696. View

11.

Horvath C, Martos P, Saxena P . Identification and quantification of eight flavones in root and shoot tissues of the medicinal plant huang-qin (Scutellaria baicalensis Georgi) using high-performance liquid chromatography with diode array and mass spectrometric detection. J Chromatogr A. 2005; 1062(2):199-207. DOI: 10.1016/j.chroma.2004.11.030. View

12.

Freeman B, Eggett D, Parker T . Synergistic and antagonistic interactions of phenolic compounds found in navel oranges. J Food Sci. 2010; 75(6):C570-6. DOI: 10.1111/j.1750-3841.2010.01717.x. View

13.

Schramm D, Collins H, German J . Flavonoid transport by mammalian endothelial cells. J Nutr Biochem. 2004; 10(4):193-7. DOI: 10.1016/s0955-2863(98)00104-1. View

14.

Martin H, Kornmann F, Fuhrmann G . The inhibitory effects of flavonoids and antiestrogens on the Glut1 glucose transporter in human erythrocytes. Chem Biol Interact. 2003; 146(3):225-35. DOI: 10.1016/j.cbi.2003.06.001. View

15.

Lee S, Lee C, Moon S, Kim E, Kim C, Kim B . Naringenin derivatives as anti-atherogenic agents. Bioorg Med Chem Lett. 2003; 13(22):3901-3. DOI: 10.1016/j.bmcl.2003.09.009. View

16.

Schijlen E, de Vos C, van Tunen A, Bovy A . Modification of flavonoid biosynthesis in crop plants. Phytochemistry. 2004; 65(19):2631-48. DOI: 10.1016/j.phytochem.2004.07.028. View

17.

Bugianesi R, Salucci M, Leonardi C, Ferracane R, Catasta G, Azzini E . Effect of domestic cooking on human bioavailability of naringenin, chlorogenic acid, lycopene and beta-carotene in cherry tomatoes. Eur J Nutr. 2004; 43(6):360-6. DOI: 10.1007/s00394-004-0483-1. View

18.

Vikram A, Jesudhasan P, Jayaprakasha G, Pillai S, Jayaraman A, Patil B . Citrus flavonoid represses Salmonella pathogenicity island 1 and motility in S. Typhimurium LT2. Int J Food Microbiol. 2010; 145(1):28-36. DOI: 10.1016/j.ijfoodmicro.2010.11.013. View

19.

Davis B, Needs P, Kroon P, Brodbelt J . Identification of isomeric flavonoid glucuronides in urine and plasma by metal complexation and LC-ESI-MS/MS. J Mass Spectrom. 2006; 41(7):911-20. DOI: 10.1002/jms.1050. View

20.

Shi R, Qiao S, Yu D, Shi X, Liu M, Jiang X . Simultaneous determination of five flavonoids from Scutellaria Barbata extract in rat plasma by LC-MS/MS and its application to pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2011; 879(19):1625-32. DOI: 10.1016/j.jchromb.2011.03.058. View