Prognosis of Neonatal Tetanus in the Modern Management Era: an Observational Study in 107 Vietnamese Infants

Overview

Journal Int J Infect Dis

Publisher Elsevier

Specialty Infectious Diseases

Date 2014 Dec 16

PMID 25499039

Citations 9

Authors

Phung Khanh Lam

Huynh T Trieu

Inke Nadia D Lubis

Huynh T Loan

Tran Thi Diem Thuy

Bridget Wills

Christopher M Parry

Nicholas P J Day

Phan T Qui

Lam Minh Yen

C Louise Thwaites

Affiliations

Soon will be listed here.

Abstract

Objectives: Most data regarding the prognosis in neonatal tetanus originate from regions where limited resources have historically impeded management. It is not known whether recent improvements in critical care facilities in many low- and middle-income countries have affected indicators of a poor prognosis in neonatal tetanus. We aimed to determine the factors associated with worse outcomes in a Vietnamese hospital with neonatal intensive care facilities.

Methods: Data were collected from 107 cases of neonatal tetanus. Clinical features on admission were analyzed against mortality and a combined endpoint of 'death or prolonged hospital stay'.

Results: Multivariable analysis showed that only younger age (odds ratio (OR) for mortality 0.69, 95% confidence interval (CI) 0.48-0.98) and lower weight (OR for mortality 0.06, 95% CI 0.01-0.54) were significantly associated with both the combined endpoint and death. A shorter period of onset (OR 0.94, 95% CI 0.88-0.99), raised white cell count (OR 1.17, 95% CI 1.02-1.35), and time between first symptom and admission (OR 3.77, 95% CI 1.14-12.51) were also indicators of mortality.

Conclusions: Risk factors for a poor outcome in neonatal tetanus in a setting with critical care facilities include younger age, lower weight, delay in admission, and leukocytosis.

Citing Articles

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Seroprotection against tetanus in southern Vietnam.

Thwaites C, Thanh T, Ny N, Nguyet L, Nhat N, Thuy C Vaccine. 2023; 41(13):2208-2213.

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Classification of Tetanus Severity in Intensive-Care Settings for Low-Income Countries Using Wearable Sensing.

Lu P, Ghiasi S, Hagenah J, Hai H, Van Hao N, Khanh P Sensors (Basel). 2022; 22(17).

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Neonatal tetanus with good outcomes at a regional referral hospital in Eastern Uganda: a case report.

Nakubulwa C, Opio E, Alekat G, Kibetenga M, Alaroker F J Med Case Rep. 2022; 16(1):54.

PMID: 35094701 PMC: 8802431. DOI: 10.1186/s13256-022-03255-4.

Severity detection tool for patients with infectious disease.

Tadesse G, Zhu T, Le Nguyen Thanh N, Hung N, Duong H, Khanh T Healthc Technol Lett. 2020; 7(2):45-50.

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