Plant Lectins, from Ancient Sugar-binding Proteins to Emerging Anti-cancer Drugs in Apoptosis and Autophagy

Overview

Journal Cell Prolif

Date 2014 Dec 10

PMID 25488051

Citations 42

Authors

Q-L Jiang

S Zhang

M Tian

S-Y Zhang

T Xie

D-Y Chen

Y-J Chen

J He

J Liu

L Ouyang

X Jiang

Affiliations

Soon will be listed here.

Abstract

Ubiquitously distributed in different plant species, plant lectins are highly diverse carbohydrate-binding proteins of non-immune origin. They have interesting pharmacological activities and currently are of great interest to thousands of people working on biomedical research in cancer-related problems. It has been widely accepted that plant lectins affect both apoptosis and autophagy by modulating representative signalling pathways involved in Bcl-2 family, caspase family, p53, PI3K/Akt, ERK, BNIP3, Ras-Raf and ATG families, in cancer. Plant lectins may have a role as potential new anti-tumour agents in cancer drug discovery. Thus, here we summarize these findings on pathway- involved plant lectins, to provide a comprehensive perspective for further elucidating their potential role as novel anti-cancer drugs, with respect to both apoptosis and autophagy in cancer pathogenesis, and future therapy.

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