Measurement Reproducibility of Magnetic Resonance Imaging-based Finite Element Analysis of Proximal Femur Microarchitecture for in Vivo Assessment of Bone Strength

Overview

Journal MAGMA

Publisher Springer

Date 2014 Dec 10

PMID 25487834

Citations 9

Authors

Gregory Chang

Alexandra Hotca-Cho

Henry Rusinek

Stephen Honig

Artem Mikheev

Kenneth Egol

Ravinder R Regatte

Chamith S Rajapakse

Affiliations

Soon will be listed here.

Abstract

Introduction: Osteoporosis is a disease of weak bone. Our goal was to determine the measurement reproducibility of magnetic resonance assessment of proximal femur strength.

Methods: This study had institutional review board approval, and written informed consent was obtained from all subjects. We obtained images of proximal femur microarchitecture by scanning 12 subjects three times within 1 week at 3T using a high-resolution 3-D FLASH sequence. We applied finite element analysis to compute proximal femur stiffness and femoral neck elastic modulus.

Results: Within-day and between-day root-mean-square coefficients of variation and intraclass correlation coefficients ranged from 3.5 to 6.6 % and 0.96 to 0.98, respectively.

Conclusion: The measurement reproducibility of magnetic resonance assessment of proximal femur strength is suitable for clinical studies of disease progression or treatment response related to osteoporosis bone-strengthening interventions.

Citing Articles

Magnetic resonance imaging based finite element modelling of the proximal femur: a short-term in vivo precision study.

Majcher K, Kontulainen S, Leswick D, Dolovich A, Johnston J Sci Rep. 2024; 14(1):7029.

PMID: 38528237 PMC: 10963727. DOI: 10.1038/s41598-024-57768-7.

The Application of Advanced Bone Imaging Technologies in Sports Medicine.

Tadros S, Epsley S, Mehta S, Jones B, Rajapakse H, Madi R Radiol Res Pract. 2023; 2023:7412540.

PMID: 38090470 PMC: 10713252. DOI: 10.1155/2023/7412540.

MRI-based mechanical competence assessment of bone using micro finite element analysis (micro-FEA): Review.

Jerban S, Alenezi S, Afsahi A, Ma Y, Du J, Chung C Magn Reson Imaging. 2022; 88:9-19.

PMID: 35091024 PMC: 8988995. DOI: 10.1016/j.mri.2022.01.009.

MRI-based assessment of proximal femur strength compared to mechanical testing.

Rajapakse C, Farid A, Kargilis D, Jones B, Lee J, Johncola A Bone. 2020; 133:115227.

PMID: 31926345 PMC: 7096175. DOI: 10.1016/j.bone.2020.115227.

Influence of bone lesion location on femoral bone strength assessed by MRI-based finite-element modeling.

Rajapakse C, Gupta N, Evans M, Alizai H, Shukurova M, Hong A Bone. 2019; 122:209-217.

PMID: 30851438 PMC: 6486650. DOI: 10.1016/j.bone.2019.03.005.

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