Intracellular Magnesium Blocks Sodium Outward Currents in a Voltage- and Dose-dependent Manner

Overview

Journal Biophys J

Publisher Cell Press

Specialty Biophysics

Date 1989 Jun 1

PMID 2548634

Citations 19

Authors

M Pusch

F Conti

W Stuhmer

Affiliations

Soon will be listed here.

Abstract

Tail currents through Na+ channels have been measured in inside-out patches from Xenopus laevis oocytes injected with cDNA-derived mRNA coding for the rat brain type II Na+ channel. It is shown that intracellular Mg2+ blocks outward currents in a voltage- and dose-dependent manner with a half blocking concentration between 3 and 4 mM at 0 mV and a voltage dependence of e-fold per 49 mV.

Citing Articles

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Single ion occupancy and steady-state gating of Na channels in squid giant axon.

Rakowski R, Gadsby D, De Weer P J Gen Physiol. 2002; 119(3):235-49.

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Variable ratio of permeability to gating charge of rBIIA sodium channels and sodium influx in Xenopus oocytes.

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Ca2+ and Na+ permeability of high-threshold Ca2+ channels and their voltage-dependent block by Mg2+ ions in chick sensory neurones.

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Use dependence of tetrodotoxin block of sodium channels: a revival of the trapped-ion mechanism.

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