Low Pressure Mediated Enhancement of Nanoparticle and Macromolecule Loading into Porous Silicon Structures

Overview

Journal Mesoporous Biomater

Publisher De Gruyter

Date 2014 Dec 9

PMID 25485265

Citations 5

Authors

Fransisca Leonard

Katrin Margulis-Goshen

Xuewu Liu

Srimeenakshi Srinivasan

Shlomo Magdassi

Biana Godin

Affiliations

Soon will be listed here.

Abstract

Ensuring drug loading efficiency and consistency is one of the most critical stages in engineering drug delivery vectors based on porous materials. Here we propose a technique to significantly enhance the efficiency of loading by employing simple and widely available methods: applying low pressure with and without centrifugation. Our results point toward the advantages the proposed method over the passive loading, especially where the size difference of loaded materials and the pore size of the porous silicon particles is smaller, an increase up to 20-fold can be observed. The technique described in the study can be used for efficient and reproducible loading of porous materials with therapeutic molecules, nanoparticles and contrast imaging agents for biomedical application.

Citing Articles

Tuning Composition of Polymer and Porous Silicon Composite Nanoparticles for Early Endosome Escape of Anti-microRNA Peptide Nucleic Acids.

Kelly 3rd I, Fletcher R, McBride J, Weiss S, Duvall C ACS Appl Mater Interfaces. 2020; 12(35):39602-39611.

PMID: 32805967 PMC: 8356247. DOI: 10.1021/acsami.0c05827.

Novel technique of insulin loading into porous carriers for oral delivery.

Eilleia S, Soliman M, Mansour S, Geneidi A Asian J Pharm Sci. 2020; 13(4):297-309.

PMID: 32104403 PMC: 7032083. DOI: 10.1016/j.ajps.2018.03.003.

Macrophage Polarization Contributes to the Anti-Tumoral Efficacy of Mesoporous Nanovectors Loaded with Albumin-Bound Paclitaxel.

Leonard F, Curtis L, Ware M, Nosrat T, Liu X, Yokoi K Front Immunol. 2017; 8:693.

PMID: 28670313 PMC: 5472662. DOI: 10.3389/fimmu.2017.00693.

Enhanced performance of macrophage-encapsulated nanoparticle albumin-bound-paclitaxel in hypo-perfused cancer lesions.

Leonard F, Curtis L, Yesantharao P, Tanei T, Alexander J, Wu M Nanoscale. 2016; 8(25):12544-52.

PMID: 26818212 PMC: 4919151. DOI: 10.1039/c5nr07796f.

Redirecting Transport of Nanoparticle Albumin-Bound Paclitaxel to Macrophages Enhances Therapeutic Efficacy against Liver Metastases.

Tanei T, Leonard F, Liu X, Alexander J, Saito Y, Ferrari M Cancer Res. 2016; 76(2):429-39.

PMID: 26744528 PMC: 4715951. DOI: 10.1158/0008-5472.CAN-15-1576.

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