Novel Medical Strategies Combating Nonmelanoma Skin Cancer

Overview

Journal Indian J Dermatol

Specialty Dermatology

Date 2014 Dec 9

PMID 25484380

Citations 4

Authors

Prasan R Bhandari

Varadraj V Pai

Affiliations

Soon will be listed here.

Abstract

The incidence of nonmelanoma skin cancer (NMSC) continues to rise, partly because of aging, the frequency of early childhood sunburns, and sporadic extreme recreational sun exposure. A nonsurgical approach to selected cutaneous malignancy could possibly reduce the cost as well as morbidity of surgical treatment for NMSC. There has been growing interest in isolating compounds that could suppress or reverse the biochemical changes necessary for cutaneous malignancies to progress by pharmacologic intervention. By targeting diverse pathways recognized as important in the pathogenesis of nonmelanoma skin cancers, a combination approach with multiple agents or addition of chemopreventative agents to topical sunscreens may offer the potential for novel and synergistic therapies in treating nonmelanoma skin cancer. This preliminary information will expand to include more therapeutic options for NMSC in the future.

Citing Articles

Therapeutic Approaches for Non-Melanoma Skin Cancer: Standard of Care and Emerging Modalities.

Sol S, Boncimino F, Todorova K, Waszyn S, Mandinova A Int J Mol Sci. 2024; 25(13).

PMID: 39000164 PMC: 11241167. DOI: 10.3390/ijms25137056.

Natural Compounds in Non-Melanoma Skin Cancer: Prevention and Treatment.

Kowalski S, Karska J, Tota M, Skinderowicz K, Kulbacka J, Drag-Zalesinska M Molecules. 2024; 29(3).

PMID: 38338469 PMC: 10856721. DOI: 10.3390/molecules29030728.

Innumerable Squamous Cell Carcinomas in Vietnam War Veteran Exposed to Chemical Defoliants.

DeSimone J, Beatson M J Clin Aesthet Dermatol. 2019; 12(8):47-50.

PMID: 31531172 PMC: 6715125.

Oxidative stress in aging human skin.

Rinnerthaler M, Bischof J, Streubel M, Trost A, Richter K Biomolecules. 2015; 5(2):545-89.

PMID: 25906193 PMC: 4496685. DOI: 10.3390/biom5020545.

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