Pertussis

Overview

Journal Hum Vaccin Immunother

Specialty Allergy & Immunology

Date 2014 Dec 9

PMID 25483523

Citations 34

Authors

Giovanni Gabutti

Chiara Azzari

Paolo Bonanni

Rosa Prato

Alberto E Tozzi

Alessandro Zanetti

Gianvincenzo Zuccotti

Affiliations

Soon will be listed here.

Abstract

Pertussis continues to be an important public-health issue. The high immunization coverage rates achieved, mainly in industrialized countries, have certainly decreased the spread of the pathogen. However, as immunity wanes, adolescents and adults play an important role in the dynamics of the infection. The surveillance system has several limitations and the underestimation of pertussis in adolescents, young adults and adults is mainly related to the atypical clinical characteristics of cases and the lack of lab confirmation. The real epidemiological impact of pertussis is not always perceived. The unavailability of comprehensive data should not hamper the adoption of active prophylactic measures designed to avoid the impact of waning immunity against pertussis. Different immunization strategies have been suggested and/or already adopted such as immunization of newborns, pre-school and school children, adolescents, adults, healthcare workers, childcare workers, pregnant women, cocoon strategy. Prevention of pertussis requires an integrated approach and the adoption of different immunization strategies, with the objective of achieving and maintaining high coverage rates.

Citing Articles

Pertussis Notification Rate and Tdpa Vaccine/Booster Coverage in Adults: An Opportunity for an Epidemiological Observatory in Primary Care.

Lapi F, Marconi E, Cricelli I, Rossi A, Mastronuzzi T, Gabutti G Infect Dis Rep. 2024; 16(5):870-879.

PMID: 39311209 PMC: 11417937. DOI: 10.3390/idr16050068.

[Epidemiological profile of pertussis in infants in Casablanca from 2012 to 2019].

Slaoui B, Saidi H, Kamal M, Kafty K, Nourlil J, Diawara I Pan Afr Med J. 2024; 46:124.

PMID: 38465012 PMC: 10924602. DOI: 10.11604/pamj.2023.46.124.42073.

The history of pertussis: from an ancient scourge to a contemporary health burden.

Galassi F, Varotto E, Martini M J Prev Med Hyg. 2024; 64(4):E507-E511.

PMID: 38379743 PMC: 10876032. DOI: 10.15167/2421-4248/jpmh2023.64.4.3163.

A phase 2 randomized controlled dose-ranging trial of recombinant pertussis booster vaccines containing genetically inactivated pertussis toxin in pregnant women.

Puthanakit T, Chokephaibulkit K, Chaithongwongwatthana S, Bhat N, Tang Y, Anugulruengkitt S Vaccine. 2023; 41(31):4541-4553.

PMID: 37330371 PMC: 10267846. DOI: 10.1016/j.vaccine.2023.06.001.

Sero-Epidemiological Study of Infection in the Italian General Population.

Grassi T, Bagordo F, Savio M, Rota M, Vitale F, Arghittu A Vaccines (Basel). 2022; 10(12).

PMID: 36560541 PMC: 9782223. DOI: 10.3390/vaccines10122130.

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