Long Non-coding RNAs As Emerging Regulators of Differentiation, Development, and Disease

Overview

Journal Transcription

Specialty Molecular Biology

Date 2014 Dec 9

PMID 25483404

Citations 179

Authors

Bijan K Dey

Adam C Mueller

Anindya Dutta

Affiliations

Soon will be listed here.

Abstract

A significant portion of the mammalian genome encodes numerous transcripts that are not translated into proteins, termed long non-coding RNAs. Initial studies identifying long non-coding RNAs inferred these RNA sequences were a consequence of transcriptional noise or promiscuous RNA polymerase II activity. However, the last decade has seen a revolution in the understanding of regulation and function of long non-coding RNAs. Now it has become apparent that long non-coding RNAs play critical roles in a wide variety of biological processes. In this review, we describe the current understanding of long non-coding RNA-mediated regulation of cellular processes: differentiation, development, and disease.

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