Do Lamin B1 and Lamin B2 Have Redundant Functions?

Overview

Journal Nucleus

Date 2014 Dec 9

PMID 25482116

Citations 8

Authors

John M Lee

Hea-Jin Jung

Loren G Fong

Stephen G Young

Affiliations

Soon will be listed here.

Abstract

Lamins B1 and B2 have a high degree of sequence similarity and are widely expressed from the earliest stages of development. Studies of Lmnb1 and Lmnb2 knockout mice revealed that both of the B-type lamins are crucial for neuronal migration in the developing brain. These observations naturally posed the question of whether the two B-type lamins might play redundant functions in the development of the brain. To explore that issue, Lee and coworkers generated "reciprocal knock-in mice" (knock-in mice that produce lamin B1 from the Lmnb2 locus and knock-in mice that produce lamin B2 from the Lmnb1 locus). Both lines of knock-in mice manifested neurodevelopmental abnormalities similar to those in conventional knockout mice, indicating that lamins B1 and B2 have unique functions and that increased production of one B-type lamin cannot compensate for the loss of the other.

Citing Articles

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Lamin B1 as a key modulator of the developing and aging brain.

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Valilou S, Karimzad Hagh J, Salimi Asl M, Abdi Rad I, Edizadeh M, Pooladi A Clin Case Rep. 2021; 9(8):e04520.

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