Functional MRI Evidence for Fine Motor Praxis Dysfunction in Children with Persistent Speech Disorders

Overview

Journal Brain Res

Specialty Neurology

Date 2014 Dec 8

PMID 25481413

Citations 15

Authors

Erin Redle

Jennifer Vannest

Thomas Maloney

Rebecca K Tsevat

Sarah Eikenberry

Barbara Lewis

Lawrence D Shriberg

Jean Tkach

Scott K Holland

Affiliations

Soon will be listed here.

Abstract

Unlabelled: Children with persistent speech disorders (PSD) often present with overt or subtle motor deficits; the possibility that speech disorders and motor deficits could arise from a shared neurological base is currently unknown. Functional MRI (fMRI) was used to examine the brain networks supporting fine motor praxis in children with PSD and without clinically identified fine motor deficits.

Methods: This case-control study included 12 children with PSD (mean age 7.42 years, four female) and 12 controls (mean age 7.44 years, four female). Children completed behavioral evaluations using standardized motor assessments and parent reported functional measures. During fMRI scanning, participants completed a cued finger tapping task contrasted passive listening. A general linear model approach identified brain regions associated with finger tapping in each group and regions that differed between groups. The relationship between regional fMRI activation and fine motor skill was assessed using a regression analysis.

Results: Children with PSD had significantly poorer results for rapid speech production and fine motor praxis skills, but did not differ on classroom functional skills. Functional MRI results showed that children with PSD had significantly more activation in the cerebellum during finger tapping. Positive correlations between performance on a fine motor praxis test and activation multiple cortical regions were noted for children with PSD but not for controls.

Conclusions: Over-activation in the cerebellum during a motor task may reflect a subtle abnormality in the non-speech motor neural circuitry in children with PSD.

Citing Articles

Neural Changes in Children With Residual Speech Sound Disorder After Ultrasound Biofeedback Speech Therapy.

Spencer C, Vannest J, Preston J, Maas E, Sizemore E, McAllister T J Speech Lang Hear Res. 2023; 66(9):3223-3241.

PMID: 37524116 PMC: 10558148. DOI: 10.1044/2023_JSLHR-22-00430.

Studying rhythm processing in speech through the lens of auditory-motor synchronization.

Luo L, Lu L Front Neurosci. 2023; 17:1146298.

PMID: 36937684 PMC: 10017839. DOI: 10.3389/fnins.2023.1146298.

Path Signature Neural Network of Cortical Features for Prediction of Infant Cognitive Scores.

Cheng J, Zhang X, Ni H, Li C, Xu X, Wu Z IEEE Trans Med Imaging. 2022; 41(7):1665-1676.

PMID: 35089858 PMC: 9246848. DOI: 10.1109/TMI.2022.3147690.

Neuroimaging of the Syllable Repetition Task in Children With Residual Speech Sound Disorder.

Spencer C, Vannest J, Maas E, Preston J, Redle E, Maloney T J Speech Lang Hear Res. 2021; 64(6S):2223-2233.

PMID: 33705667 PMC: 8740709. DOI: 10.1044/2020_JSLHR-20-00269.

Estimates of the prevalence of speech and motor speech disorders in persons with complex neurodevelopmental disorders.

Shriberg L, Strand E, Jakielski K, Mabie H Clin Linguist Phon. 2019; 33(8):707-736.

PMID: 31221012 PMC: 6633911. DOI: 10.1080/02699206.2019.1595732.

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