Use of Pharmacologic Agents for Modulation of Ischaemia-Reperfusion Injury After Hepatectomy: A Questionnaire Study of the LiverMetSurvey International Registry of Hepatic Surgery Units

Overview

Journal HPB Surg

Specialties Gastroenterology
General Surgery

Date 2014 Dec 6

PMID 25477707

Citations 1

Authors

Santhalingam Jegatheeswaran

Saurabh Jamdar

Thomas Satyadas

Aali J Sheen

Rene Adam

Ajith K Siriwardena

Affiliations

Soon will be listed here.

Abstract

Objectives. This study is a questionnaire survey on the use of pharmacological agents to modify liver ischaemia-reperfusion (IR) injury in patients undergoing hepatectomy for colorectal liver metastases with the target population being those units participating in the LiverMetSurvey international registry. Methods. Members of LiverMetSurvey were sent an online questionnaire using SurveyMonkey comprising ten questions on the use of pharmacological agents to modulate hepatic IR injury in the perioperative period after hepatectomy. The questionnaire was sent to 446 clinicians registered with the LiverMetSurvey. There were 83 (19%) respondents. Results. Fifty-two (77% of 68 respondents to this question) never used pharmacological agents to modify liver IR injury during hepatectomy. Thirteen (19%) used pharmacological agents selectively. Three (4%) used these routinely. N-Acetylcysteine was the most widely used pharmacological agent with equal distribution of use around intraoperative and postoperative periods. Conclusions. This is believed to be the first survey on the use of pharmacological agents to modify liver IR injury. The target population is clinicians involved in liver resection. The results show that pharmacological modulation is used by only a minority of respondents to this questionnaire and that when this treatment is selected, N-acetylcysteine is the most frequently used.

Citing Articles

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Tokac M, Bacanli M, Dumlu E, Aydin S, Engin M, Bozkurt B Turk J Pharm Sci. 2020; 14(3):257-263.

PMID: 32454622 PMC: 7227925. DOI: 10.4274/tjps.49369.

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