Keeping an Eye on SOXC Proteins

Overview

Journal Dev Dyn

Publisher Wiley

Specialty Anatomy & Histology

Date 2014 Dec 6

PMID 25476579

Citations 7

Authors

Lakshmi Pillai-Kastoori

Wen Wen

Ann C Morris

Affiliations

Soon will be listed here.

Abstract

The formation of a mature, functional eye requires a complex series of cell proliferation, migration, induction among different germinal layers, and cell differentiation. These processes are regulated by extracellular cues such as the Wnt/BMP/Hh/Fgf signaling pathways, as well as cell intrinsic transcription factors that specify cell fate. In this review article, we provide an overview of stages of embryonic eye morphogenesis, extrinsic and intrinsic factors that are required for each stage, and pediatric ocular diseases that are associated with defective eye development. In addition, we focus on recent findings about the roles of the SOXC proteins in regulating vertebrate ocular development and implicating SOXC mutations in human ocular malformations.

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