Kiss1 Mutant Placentas Show Normal Structure and Function in the Mouse

Overview

Journal Placenta

Publisher Elsevier

Specialties Gynecology & Obstetrics
Physiology
Reproductive Medicine

Date 2014 Dec 4

PMID 25468546

Citations 10

Authors

A M Herreboudt

V R L Kyle

J Lawrence

J Doran

W H Colledge

Affiliations

Soon will be listed here.

Abstract

Introduction: Kisspeptins, encoded by the Kiss1 gene, are a set of related neuropeptides that are required for activation of the mammalian reproductive axis at puberty and to maintain fertility. In addition, kisspeptin signaling via the G-protein coupled receptor GPR54 (KISS1R) has been suggested to regulate human placental formation and correlations have been found between altered kisspeptin levels in the maternal blood and the development of pre-eclampsia.

Methods: We have used Kiss1 and Gpr54 mutant mice to investigate the role of kisspeptin signaling in the structure and function of the mouse placenta.

Results: Expression of Kiss1 and Gpr54 was confirmed in the mouse placenta but no differences in birth weight were found in mice that had been supported by a mutant placenta during fetal development. Stereological measurements found no differences between Kiss1 mutant and wild-type placentas. Measurement of amino-acid and glucose transport across the Kiss1 mutant placentas at E15.5 days did not reveal any functional defects.

Discussion: These data indicate that mouse placentas can develop a normal structure and function without kisspeptin signaling and can support normal fetal development and growth.

Citing Articles

Kisspeptin upregulates β-cell serotonin production during pregnancy.

Hill T, Smith L, Ruz-Maldonado I, Jones P, Bowe J J Endocrinol. 2023; 260(2).

PMID: 37997938 PMC: 10762540. DOI: 10.1530/JOE-23-0218.

Kisspeptin Is Upregulated at the Maternal-Fetal Interface of the Preeclamptic-like BPH/5 Mouse and Normalized after Synchronization of Sex Steroid Hormones.

Gomes V, Woods A, Crissman K, Landry C, Beckers K, Gilbert B Reprod Med (Basel). 2023; 3(4):263-279.

PMID: 37538930 PMC: 10399610. DOI: 10.3390/reprodmed3040021.

Performance of plasma kisspeptin as a biomarker for miscarriage improves with gestational age during the first trimester.

Abbara A, Al-Memar M, Phylactou M, Kyriacou C, Eng P, Nadir R Fertil Steril. 2021; 116(3):809-819.

PMID: 34053677 PMC: 8445632. DOI: 10.1016/j.fertnstert.2021.04.031.

Kisspeptins and Glucose Homeostasis in Pregnancy: Implications for Gestational Diabetes Mellitus-a Review Article.

Musa E, Matjila M, Levitt N Reprod Sci. 2021; 29(2):321-327.

PMID: 33398849 DOI: 10.1007/s43032-020-00437-7.

Peripheral action of kisspeptin at reproductive tissues-role in ovarian function and embryo implantation and relevance to assisted reproductive technology in livestock: a review.

DOcchio M, Campanile G, Baruselli P Biol Reprod. 2020; 103(6):1157-1170.

PMID: 32776148 PMC: 7711897. DOI: 10.1093/biolre/ioaa135.

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